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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 828754, 7 pages
http://dx.doi.org/10.1155/2013/828754
Research Article

A Brief Analysis of Traditional Chinese Medical Elongated Needle Therapy on Acute Spinal Cord Injury and Its Mechanism

1Research Institute of Acupuncture and Moxibustion, Xiaoshan Traditional Chinese Medical Hospital, Zhejiang 311200, China
2Research Institute of Acupuncture and Moxibustion, Zhejiang Chinese Medical University, Hangzhou 31012, China
3Research Institute of Acupuncture and Moxibustion, Medical College of Xiamen University, Xiamen 361005, China
4Department of Acupuncture and Moxibustion, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China

Received 26 September 2013; Revised 22 October 2013; Accepted 22 October 2013

Academic Editor: Calvin Yu-Chian Chen

Copyright © 2013 Mengxuan Du et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Acute spinal cord injury is one of the most common and complicated diseases among human spinal injury. We aimed to explore the effect of point-through-point acupuncture therapy with elongated needles on acute spinal cord injury in rabbits and its possible mechanism. Adult rabbits were randomly divided into a model group, elongated needle therapy group, and blank group. Immunohistochemical staining showed that the protein levels of Fas and caspase-3 in the model group were significantly higher than those in the blank group at each time point ( ) and significantly lower than those in the elongated needle therapy group on the 3rd and 5th days after operation ( ). RT-PCR showed that Fas and caspase-3 mRNA levels in the model group and elongated needle therapy group were significantly higher than those in the blank group ( , 0.01). The mRNA levels of Fas and caspase-3 in the elongated needle therapy group were significantly lower than those in model group on the 3rd day ( , 0.01). Therefore, we confirmed that elongated needle therapy has an obvious effect on acute spinal cord injury in rabbits. Its mechanism is made possible by inhibiting the expression of the Fas→caspase-3 cascade, thereby inhibiting cell apoptosis after spinal cord injury.