Honey as a Potential Natural Anticancer Agent: A Review of Its Mechanisms

Figure 2

The effect of honey on apoptotic pathway. Honey exerts apoptotic effect through upregulation and modulation of proapoptotic proteins (p53, Bax, caspase 3, and caspase 9) and downregulation of antiapoptotic proteins (Bcl-2) [14, 23, 31]. Bcl-2: B cell lymphoma 2 protein; Cyt. C: cytochrome C; Apaf-1—apoptotic protease activating factor 1; TNF: tumor necrosis factor; TRAIL: TNF related apoptosis-inducing ligand; TRADD: TNFR associated death domain protein.