Oral Administration of Alkylglycerols Differentially Modulates High-Fat Diet-Induced Obesity and Insulin Resistance in Mice

Table 1

The effect of selachyl alcohol (SA) or batyl alcohol (BA) supplementation on body weights, tissue weights, and food consumption.

		Treatment^1
							P value^6	P value	P value
Item	ND	HF	HF + 20 mg/kg SA	HF + 200 mg/kg SA	HF + 20 mg/kg BA	HF + 200 mg/kg BA	(HF)	(SA)	(BA)
Initial body wt^2 (g)	14.05±0.18^5	14.27±0.21	14.38±0.23	14.36±0.27	14.22±0.29	14.33±0.23	0.299	0. 943	0.950
End-point body wt^3 (g)	25.92±0.56	35.21±0.57	36.48±0.59	32.80±0.54^∗	36.35±0.44	36.17±0.39	<0.001	<0.001	0.087
Net weight gain^4 (g)	11.87±0.63	20.93±0.51	22.10±0.67	18.43±0.57^∗	22.12±0.55	21.83±0.54	<0.001	<0.001	0.062
Epididymal fat^3(%)	1.76±0.29	2.39±0.09	2.20±0.05	2.02±0.10^∗	2.48±0.08	2.64±0.07	<0.001	0.019	0.130
Liver weight^3 (%)	3.86±0.04	3.29±0.05	3.42±0.07	3.49±0.08	3.37±0.02	3.18±0.03^†	<0.001	0.150	0.011
Food intake (g/mouse/day)	2.80±0.05	2.64±0.04	2.57±0.04	2.58±0.05	2.64±0.06	2.69±0.05	0.005	0.563	0.729

1ND: normal diet; HF: high-fat diet; SA: selachyl alcohol; BA: batyl alcohol.2Measured before dietary intervention. 3Measured after 8-week feeding period. 4Difference between end-point body weight and initial body weight. 5Values are mean ± SEM. Means with a mark (*) in HF + 20 mg/kg  SA or HF + 200 mg/kg SA group differ significantly from the HF diet group. Means with a mark (^†) in HF + 20 mg/kg BA or HF + 200 mg/kg BA group differ significantly from the HF diet group. 6P value (HF) indicates the effect of HF treatment. P value (SA) indicates the effect of different doses of SA supplements on HF fed mice. P value (BA) indicates the effect of different doses of BA supplements on HF fed mice.