Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs

Table 3

Mean (±S.D.) morphometric values for colon toxicity indicators in control mice (0.000 mg/g extract, 𝑁=4) and mice administered 0.125 mg/g (𝑁=8), 0.5 mg/g (𝑁=7), and 1.0 mg/g (𝑁=6) of muricid extract (ME).

Colon region	ME dose; (mg/g)	Crypt height; (cells/crypt)	Crypt cell density; (cells/µm)
Proximal	0.000	13.66±1.90	0.18±0.05
	0.125	13.78±2.31	0.17±0.05
	0.500	14.00±2.64	0.19±0.06
	1.000	13.50±2.71	0.18±0.05
Distal	0.000	22.77±3.34	0.21±0.07
	0.125	23.23±3.53	0.19±0.05
	0.500	22.43±3.81	0.18±0.04
	1.000	23.05±4.01	0.19±0.04