Gastrointestinal and Hepatotoxicity Assessment of an Anticancer Extract from Muricid Molluscs

Table 4

Frequency and mean morphometric values (±S.D.) for hepatotoxicity indicators in control mice (0.0 mg/g, 𝑁=4) and mice administered 0.125 mg/g (𝑁=8), 0.5 mg/g (𝑁=7), and 1.0 mg/g (𝑁=6) of muricid extract (ME). Significant differences between control and treated mice are indicated by * (Tukey, 𝑃<0.05; Mann-Whitney, 𝑃<0.017. Abbreviations: FOV: field of view; IF: inflammatory foci.

ME dose; (mg/g)	Hepatocyte density (cells/mm^2)	Hepatocyte diameter; (µm)	Sinusoid diameter; (µm)	IF frequency; (foci/20 FOV)
0.000	23.73±4.31	18.98±3.20	4.47±1.07	0.15±0.42
0.125	30.16±5.51^∗	15.16±2.43^∗	5.93±2.09^∗	0.55±0.90^∗
0.500	27.68±5.95^∗	16.46±2.65^∗	5.91±1.57^∗	0.73±1.11^∗
1.000	24.80±4.98	17.29±2.88^∗	5.43±1.36^∗	0.76±0.07^∗