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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 841580, 9 pages
http://dx.doi.org/10.1155/2013/841580
Research Article

Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents

1Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil
2Departamento de Farmácia, Universidade Estadual de Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil
3Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil
4Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Avenida Colombo 5790, 87020-900 Maringá, PR, Brazil
5Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Avenida Colombo 5790, Bloco B08, 87020-900 Maringá, PR, Brazil

Received 4 April 2013; Revised 25 June 2013; Accepted 25 June 2013

Academic Editor: Ulysses Paulino Albuquerque

Copyright © 2013 Marco Antonio Costa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Stryphnodendron adstringens has a high tannin content and is used as an antiseptic and antimicrobial and in the treatment of leucorrhea, gonorrhea, wound healing, and gastritis. The present study evaluated the toxic effects of the heptamer prodelphinidin (F2) from the stem bark of S. adstringens in rodents. In the acute toxicity test, the mice that received oral doses exhibited reversible effects, with an LD50 of 3.015  . In the chronic toxicity test at 90 days, Wistar rats were treated with different doses of F2 (10, 100, and 200  ). In the biochemical, hematological, and histopathological examinations and open-field test, the different dose groups did not exhibit significant differences compared with controls. The present results indicate that F2 from the stem bark of S. adstringens caused no toxicity with acute and chronic oral treatment in rodents at the doses administered.