Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents
Table 1
Acute toxicity of F2 of Stryphnodendron adstringens administered orally in mice.
F2 S. adstringens
Observed changes
dose (mg·kg−1)
No. of deaths
Diarrhea
Piloerection
Hypoactivity
Hyperventilation
Ptosis
Hypothermia
Motor impairment
Catatonia
Hypnosis/sedation
Control
0
No
No
No
No
No
No
No
No
No
500
0
No
No
No
No
No
No
No
No
No
1,000
0
No
No
No
No
No
No
No
No
No
2,000
2
Reversible after 8 h (2)
Reversible after 72 h (5)
No
No
No
No
No
No
No
3,000
7
Reversible after 8 h (1)
Reversible after 7 d (6)
Reversible after 48 h (4)
Reversible after 48 h (2)
Reversible after 48 h (1)
Reversible after 48 h (1)
Reversible after 48 h (1)
No
No
4,000
9
Reversible after 8 h (6)
Reversible after 7 d (12)
Reversible after 48 h (9)
Reversible after 4 h (2)
No
Reversible after 48 h (4)
No
Reversible after 1 h (1)
No
5,000
11
Reversible after 48 h (6)
Reversible after at 14 d (10)
Reversible after 48 h (5)
Reversible after 12 h (8)
Reversible after 48 h (1)
Reversible after 48 h (4)
Reversible after 1 h (1)
No
Reversible after 12 h (1)
No: no toxic symptoms observed. The numbers in parentheses indicate the number of animals that showed the changes. The mice were observed daily for signs of toxicity (behavioral changes and mortality) for 14 days.
