Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents

Table 2

Effect of F2 of Stryphnodendron adstringens on the weights of organs of mice.

Organs	F2 S. adstringens (mg·kg^−1)
	Control	500	1,000	2,000	3,000	4,000	5,000
Male
Liver	3.27±0.4	2.57±0.3	2.87±0.2	2.75±0.3	2.58±0.2	2.32±0.3^∗	2.45±0.6^∗
Spleen	0.31±0.04	0.24±0.02	0.27±0.06	0.30±0.07	0.20±0.05	0.20±0.03	0.20±0.06
Lungs	0.48±0.01	0.35±0.03	0.40±0.04	0.35±0.04	0.46±0.11	0.39±0.06	0.46±0.16
Heart	0.31±0.03	0.25±0.04	0.27±0.04	0.28±0.04	0.34±0.05	0.29±0.07	0.32±0.04
Kidneys	0.95±0.09	0.67±0.05	0.82±0.05	0.70±0.09	0.81±0.06	0.64±0.10	0.72±0.12
Female
Liver	2.22±0.3	1.94±0.2	2.04±0.3	1.93±0.3	1.98±0.5	1.92±0.4^∗	1.68±0.2^∗
Spleen	0.25±0.04	0.20±0.06	0.28±0.06	0.29±0.09	0.24±0.07	0.26±0.08	0.19±0.03
Lungs	0.38±0.07	0.32±0.06	0.33±0.04	0.36±0.07	0.43±0.15	0.50±0.15	0.47±0.14
Heart	0.20±0.04	0.17±0.04	0.21±0.06	0.24±0.03	0.25±0.07	0.25±0.06	0.19±0.03
Kidneys	0.51±0.06	0.44±0.08	0.49±0.03	0.55±0.07	0.52±0.07	0.51±0.09	0.49±0.03

Values expressed as mean ± DP (standard deviation). ANOVA or Kruskal-Wallis tests. *𝑃<0.05 compared to control.