Acute and Chronic Toxicity of an Aqueous Fraction of the Stem Bark of Stryphnodendron adstringens (Barbatimão) in Rodents

Table 5

Hematological results in male and female rats orally treated with F2 of S. adstringens for 90 days.

Parameters	Controls	F2 (mg·kg^−1)
		10	100	200
Male
WBC (×10^3 mm^−3)	10.6±3.7	7.1±0.6	8.7±2.8	7.2±1.6
Segmented (%)	20.9±8.9	16.0±6.5	15.9±4.9	16.1±4.6
Eosinophil (%)	2.3±0.8	1.9±0.8	1.5±0.5	2.3±0.9
Lymphocyte (%)	66.6±11.8	75.2±9.7	79.3±5.2	78.6±5.6
Monocyte (%)	3.4±0.7	3.1±0.8	3.1±0.5	3.0±0.9
RBC (×10^6 mm^−3)	8.16±0.3	8.16±0.4	8.22±0.5	8.50±0.3
Haemoglobin (g/dL)	17.1±0.6	16.0±0.9	16.4±1.1	17.0±0.6
Haematocrit (%)	46.7±1.8	46.3±2.5	46.5±3.2	47.7±2.1
MCV (fL)	57.3±1.2	56.7±1.2	56.5±1.2	55.9±1.4
MCH (pg)	20.9±0.5	20.0±0.4^∗	19.9±0.5^∗	20.0±0.4^∗
MCHC (%)	36.5±0.7	35.6±0.8	35.1±0.3^∗	35.8±0.8
Platelet (×10^3 mm^−3)	679±171	929±108^∗	961±105^∗	895±106
Female
WBC (×10^3 mm^−3)	7.2±1.1	10.5±4.3	8.3±2.6	7.9±1.9
Segmented (%)	18.2±8.0	20.2±6.9	14.3±4.3	19.0±9.0
Eosinophil (%)	2.5±0.9	2.1±0.9	2.2±0.9	2.0±1.0
Lymphocyte (%)	76.2±8.3	74.3±8.0	76.5±15.2	75.6±10.3
Monocyte (%)	3.2±0.8	3.1±0.7	2.9±0.8	3.2±1.0
RBC (×10^6 mm^−3)	7.35±0.3	7.27±0.6	7.26±0.7	7.5±0.4
Haemoglobin (g/dL)	15.6±0.5	15.3±1.2	15.3±1.6	15.8±0.9
Haematocrit (%)	43.7±1.8	42.9±3.9	45.6±5.3	44.6±2.4
MCV (fL)	59.5±1.1	58.9±1.8	59.9±1.9	59.4±1.1
MCH (pg)	21.2±0.4	21.0±0.5	21.2±1.1	21.1±0.3
MCHC (%)	35.7±0.8	35.6±1.3	35.3±1.9	35.7±0.5
Platelet (×10^3 mm^−3)	878±124	884±187	856±168	730±202

The data are expressed as mean ± SEM. *𝑃<0.05, compared with control group (ANOVA or Kruskal-Wallis test).