Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide

Table 2

Dosage and toxicity of Andrographis paniculata and its major natural product andrographolide.

Products name	Dosage/duration/route	Experimental models	Toxic effects	References
Andrographolide	10 mg/kg for 3 weeks	Human	No	[3]
Andrographolide	500 mg/kg bw for 7 days i.p.	Mice	No	[4]
Andrographolide	25–75 μM	Platelets	No cytotoxicity	[15]
A.  paniculata	20 mg/kg bw for 60 days, oral	Rats	No	[71]
Andrographolide	22–55 μg/kg, i.v.	Mice	Lower mortality	[97]
A.  paniculata	1 g/kg/day for 4, 6, and 8 weeks	Rats	No	[120]
Andrographolide	100 mg/kg, i.p.	Mice	No	[121]
Andrographolide	10 mg/kg, i.v.	Rats	No	[123]

i.p.: intraperitoneal; i.v.: intravenous; and bw: body weight.