Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells
Figure 5
Inhibition in Sirt1 partially compromised the beneficial effects of BDMC on t-BHP-induced cellular senescence in WI38 cells. WI38 cells were pretreated with NAM (40 mM) for 1 h (a), or transfected with Sirt1 siRNA (b), then incubated in the presence or absence of BDMC (20 μM) for 48 h, followed by exposure to t-BHP treatment. Cell proliferation was then determined by MTT assay. Data were presented as mean ± SD of three independent experiments. ; .
