Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products

<table>Mechanism of antiplatelet action of natural products by cAMP levels. PDE3: phosphodiesterase-3; PKA: protein kinase A; PLC: phospholipase; DAG: diacylglycerol; IP3: inositol trisphosphate; PIP2: phosphatidylinositol 4,5-bisphosphate; PKC:  protein kinase C; PSGL-1: P-selectin glycoprotein ligand-1.</table>

Evidence-Based Complementary and Alternative Medicine

fig2

Figure 2

Figure 2: Relationship between Platelet PPARs, cAMP Levels, and P-Selectin Expression: Antiplatelet Activity of Natural Products 