Research Article

Effects of Korean Red Ginseng and HAART on vif Gene in 10 Long-Term Slow Progressors over 20 Years: High Frequency of Deletions and G-to-A Hypermutation

Table 2

Distribution of defective vif gene.

PatientOn-KRGOn-HAART/KRG
No. of genesStop codonNo. of genesStop codon

87-05201NDNDNDND
89-1799000
90-0537118400
90-183515203a012a
90-5014115000
91-2035120000
92-135314220013
93-0418112510
93-60281120060
96-512621000

Total2753b42915712b725

gΔ and sΔ denote gross deletion and in-frame small deletion, respectively.
HAART: highly active antiretroviral therapy; ND: not determined.
aTwo out of three genes contained both stop codon and sΔ.
.
for the sum of 3 kinds of defective genes (36/275 versus 42/157).
Fifty-two vif genes at baseline obtained from serum using RT-PCR were all wild types. *Control patients ( ) revealed premature stop codon in one out of 106 vif genes.