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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 873907, 8 pages
Research Article

A Randomized Clinical Trial of Schinus terebinthifolius Mouthwash to Treat Biofilm-Induced Gingivitis

1Department of Physiological Sciences, Piracicaba Dental School, State University of Campinas, 13.417-095 Piracicaba, SP, Brazil
2Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, 13.417-095 Piracicaba, SP, Brazil
3School of Dentistry, Federal University of Paraiba, 58.035-260 Joao Pessoa, PB, Brazil
4Department of Clinics and Social Dentistry, School of Dentistry, Federal University of Paraiba, 58.038-040 Joao Pessoa, PB, Brazil
5Department of Dentistry, School of Dentistry, State University of Paraiba, 58.038-300 Campina Grande, PB, Brazil

Received 26 February 2013; Revised 3 May 2013; Accepted 7 May 2013

Academic Editor: Vincenzo De Feo

Copyright © 2013 Irlan de Almeida Freires et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. This study aimed to investigate the efficacy of a Schinus terebinthifolius (ST) mouthwash in reducing gingival inflammation levels (GI) and biofilm accumulation (BA) in children with gingivitis. Methods. This was a randomized, controlled, triple blind, and phase II clinical trial, with children aged 9–13 years presenting with biofilm-induced gingivitis. The sample was randomized into experimental (0.3125% ST, ) and control (0.12% chlorhexidine/CHX, ) groups. Products were masked as regards color, flavor and aroma. Intervention protocol consisted in supervised rinsing of 10 mL/day for 01 minute for 10 days. Gingival bleeding and simplified oral hygiene indexes were used to assess the efficacy variables, measured at baseline and after intervention by calibrated examiners. Data were statistically treated with paired t-test, unpaired t-test, and Wilcoxon and Mann-Whitney tests (α = .05). Results. It was found that both ST and CHX were able to significantly reduce GI levels after 10 days and there was no significant difference between them . CHX was the only product able to significantly reduce BA after 10 days when compared to baseline . Conclusion. ST mouthwash showed significant anti-inflammatory activity (equivalent to CHX), but it was not able to reduce biofilm accumulation.