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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 874367, 7 pages
http://dx.doi.org/10.1155/2013/874367
Research Article

The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction

1Programa de Pós-Graduação em Ciências Biológicas, Universidade Estadual de Maringá, Avenida Colombo 5790, PR 87020-900 Maringá, Brazil
2Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Avenida Colombo 5790, PR 87020-900 Maringá, Brazil
3Departamento de Química, Universidade Estadual de Maringá, Avenida Colombo 5790, PR 87020-900 Maringá, Brazil
4Programa de Pós-Graduação em Ciências Biológicas, Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Bloco B-08, Universidade Estadual de Maringá, Avenida Colombo 5790, PR 87020-900 Maringá, Brazil

Received 21 January 2013; Accepted 27 May 2013

Academic Editor: Valdir Cechinel Filho

Copyright © 2013 Hélito Volpato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [13 citations]

The following is the list of published articles that have cited the current article.

  • Josiane A. Monteiro, Ivânia T.A. Schuquel, Thiago L. de Almeida, Silvana M. de O. Santin, Cleuza C. da Silva, Lucas U.R. Chiavelli, Ana L.T.G. Ruiz, João E. de Carvalho, Débora B. Vendramini-Costa, Celso V. Nakamura, Débora B. Scariot, Vanessa Kaplum, Ricardo T. Faria, and Armando M. Pomini, “Oncibauerins A and B, new flavanones from Oncidium baueri (Orchidaceae),” Phytochemistry Letters, 2014. View at Publisher · View at Google Scholar
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  • Patrícia de Almeida Machado, Vinícius Zamprogno Mota, Ana Clara de Lima Cavalli, Gustavo Senra Gonçalves de Carvalho, Adilson David da Silva, Jacy Gameiro, Alexandre Cuin, and Elaine Soares Coimbra, “High selective Antileishmanial activity of vanadium complex with stilbene derivative,” Acta Tropica, 2015. View at Publisher · View at Google Scholar
  • Luciana M. R. Antinarelli, Rafael M. P. Dias, Isabela O. Souza, Wallace P. Lima, Jacy Gameiro, Adilson D. da Silva, and Elaine S. Coimbra, “4-Aminoquinoline Derivatives as Potential Antileishmanial Agents,” Chemical Biology & Drug Design, 2015. View at Publisher · View at Google Scholar
  • Solange C. Martins, Danielle Lazarin-Bidóia, Vânia C. Desoti, Hugo Falzirolli, Cleuza C. da Silva, Tania Ueda-Nakamura, Sueli de O. Silva, and Celso V. Nakamura, “1,3,4-Thiadiazole derivatives of R-(+)-limonene benzaldehyde-thiosemicarbazones cause death in Trypanosoma cruzi through oxidative stress,” Microbes and Infection, 2016. View at Publisher · View at Google Scholar
  • Vanessa Kaplum, Juliana Cogo, Diego Pereira Sangi, TYnia Ueda-Nakamura, Arlene Gonalves Correa, and Celso Vataru Nakamura, “In Vitro and In Vivo Activities of 2,3-Diarylsubstituted Quinoxaline Derivatives against Leishmania amazonensis,” Antimicrobial Agents And Chemotherapy, vol. 60, no. 6, pp. 3433–3444, 2016. View at Publisher · View at Google Scholar
  • Penta Ashok, Subhash Chander, Larry M.C. Chow, Iris L.K. Wong, Rajnish Prakash Singh, Prabhat Nath Jha, and Murugesan Sankaranarayanan, “Synthesis and in-vitro anti-leishmanial activity of (4-arylpiperazin-1-yl)(1-(thiophen-2-yl)-9 H -pyrido[3,4- b ]indol-3-yl)methanone derivatives,” Bioorganic Chemistry, vol. 70, pp. 100–106, 2017. View at Publisher · View at Google Scholar
  • Murugesan Sankaranarayanan, Penta Ashok, Subhash Chander, and Terry K. Smith, “Design, synthesis and biological evaluation of piperazinyl-β-carbolinederivatives as anti-leishmanial agents,” European Journal of Medicinal Chemistry, vol. 150, pp. 559–566, 2018. View at Publisher · View at Google Scholar
  • Paula Baréa, Valéria Aquilino Barbosa, Danielle Lazarin Bidóia, Jéssica Carreira de Paula, Talitha Fernandes Stefanello, Willian Ferreira da Costa, Celso Vataru Nakamura, and Maria Helena Sarragiotto, “Synthesis, antileishmanial activity and mechanism of action studies of novel β -carboline-1,3,5-triazine hybrids,” European Journal of Medicinal Chemistry, 2018. View at Publisher · View at Google Scholar