Research Article

Effect of Electroacupuncture on Rat Ischemic Brain Injury: Importance of Stimulation Duration

Figure 1

EA-induced changes in cerebral infarct size in a time-dependent manner. The brain slices were subjected to TTC staining and the ischemic infarct volume was quantified by a computerized image system. The slices on the right of each column show the backside of the left slices. Note that the infarct region (pale-white portion) was mainly located in the striatum and the frontoparietal cortex in the right hemisphere. The MCAO-induced infarction (a) was significantly reduced by EA at Du 20 and Du 26 acupoints for 5 min (b), 15 min (c), and 30 min (d). In contrast, EA for 45 min (e) enabled no protection against the cerebral infarction.
878521.fig.001a
(a) Ischemia (MCAO-60 min)
878521.fig.001b
(b) Ischemia + EA-5 min
878521.fig.001c
(c) Ischemia + EA-15 min
878521.fig.001d
(d) Ischemia + EA-30 min
878521.fig.001e
(e) Ischemia + EA-45 min