Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 879746, 8 pages
http://dx.doi.org/10.1155/2013/879746
Research Article

Melatonin Suppresses the Expression of 45S Preribosomal RNA and Upstream Binding Factor and Enhances the Antitumor Activity of Puromycin in MDA-MB-231 Breast Cancer Cells

1College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea
2College of Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea

Received 12 February 2013; Revised 7 March 2013; Accepted 7 March 2013

Academic Editor: Mohamed Eddouks

Copyright © 2013 Ji Hoon Jung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. J. Clarke, “WITHDRAWN: multi-agent chemotherapy for early breast cancer,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD000487, 2008. View at Google Scholar · View at Scopus
  2. A. Lerchl and R. J. Reiter, “Treatment of sleep disorders with melatonin,” The British Medical Journal, vol. 345, Article ID e6968, 2012. View at Publisher · View at Google Scholar
  3. D. P. Cardinali, V. Srinivasan, A. Brzezinski, and G. M. Brown, “Melatonin and its analogs in insomnia and depression,” Journal of Pineal Research, vol. 52, no. 4, pp. 365–375, 2012. View at Publisher · View at Google Scholar
  4. S. R. Pandi-Perumal, A. S. Bahammam, G. M. Brown et al., “Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes,” Neurotoxicity Research, vol. 23, no. 3, pp. 267–300, 2013. View at Publisher · View at Google Scholar
  5. A. Galano, D. X. Tan, and R. J. Reiter, “Melatonin as a natural ally against oxidative stress: a physicochemical examination,” Journal of Pineal Research, vol. 51, no. 1, pp. 1–16, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Prunet-Marcassus, M. Desbazeille, A. Bros et al., “Melatonin reduces body weight gain in sprague dawley rats with diet-induced obesity,” Endocrinology, vol. 144, no. 12, pp. 5347–5352, 2003. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Dominguez-Rodriguez, “Melatonin in cardiovascular disease,” Expert Opinion on Investigational Drugs, vol. 21, no. 11, pp. 1593–1596, 2012. View at Publisher · View at Google Scholar
  8. E. J. Sanchez-Barcelo, M. D. Mediavilla, D. X. Tan, and R. J. Reiter, “Scientific basis for the potential use of melatonin in bone diseases: osteoporosis and adolescent idiopathic scoliosis,” Journal of Osteoporosis, vol. 2010, Article ID 830231, 10 pages, 2010. View at Publisher · View at Google Scholar
  9. M. Sanchez-Hidalgo, J. M. Guerrero, I. Villegas, G. Packham, and C. A. de la Lastra, “Melatonin, a natural programmed cell death inducer in cancer,” Current Medicinal Chemistry, vol. 19, no. 22, pp. 3805–3821, 2012. View at Google Scholar
  10. W. Koh, S. J. Jeong, H. J. Lee et al., “Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5′-adenosine monophosphate-activated kinase-alpha in human leukemia HL-60 cells,” Journal of Pineal Research, vol. 50, no. 4, pp. 367–373, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. V. Alvarez-Garcia, A. González, C. Alonso-González, C. Martínez-Campa, and S. Cos, “Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells,” Journal of Pineal Research, 2012. View at Publisher · View at Google Scholar
  12. C. Martínez-Campa, A. González, M. D. Mediavilla et al., “Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells,” The British Journal of Cancer, vol. 101, no. 9, pp. 1613–1619, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. D. Ruggero and P. P. Pandolfi, “Does the ribosome translate cancer?” Nature Reviews Cancer, vol. 3, no. 3, pp. 179–192, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. M. L. Birnstiel, M. I. H. Chipchase, and B. B. Hyde, “The nucleolus, a source of ribosomes,” Biochimica et Biophysica Acta, vol. 76, pp. 454–462, 1963. View at Google Scholar · View at Scopus
  15. L. Montanaro, D. Treré, and M. Derenzini, “Nucleolus, ribosomes, and cancer,” The American Journal of Pathology, vol. 173, no. 2, pp. 301–310, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Derenzini, D. Trerè, A. Pession, M. Govoni, V. Sirri, and P. Chieco, “Nucleolar size indicates the rapidity of cell proliferation in cancer tissues,” Journal of Pathology, vol. 191, no. 2, pp. 181–186, 2000. View at Google Scholar
  17. D. Williamson, Y. J. Lu, C. Fang, K. Pritchard-Jones, and J. Shipley, “Nascent pre-rRNA overexpression correlates with an adverse prognosis in alveolar rhabdomyosarcoma,” Genes Chromosomes and Cancer, vol. 45, no. 9, pp. 839–845, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. K. M. Hannan, E. Sanij, L. I. Rothblum, R. D. Hannan, and R. B. Pearson, “Dysregulation of RNA polymerase I transcription during disease,” Biochimica et Biophysica Acta, vol. 1829, no. 3-4, pp. 342–360, 2013. View at Publisher · View at Google Scholar
  19. H. M. Jantzen, A. Admon, S. P. Bell, and R. Tjian, “Nucleolar transcription factor hUBF contains a DNA-binding motif with homology to HMG proteins,” Nature, vol. 344, no. 6269, pp. 830–836, 1990. View at Publisher · View at Google Scholar · View at Scopus
  20. D. Drygin, W. G. Rice, and I. Grummt, “The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer,” Annual Review of Pharmacology and Toxicology, vol. 50, pp. 131–156, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Jordan and M. Carmo-Fonseca, “Cisplatin inhibits synthesis of ribosomal RNA in vivo,” Nucleic Acids Research, vol. 26, no. 12, pp. 2831–2836, 1998. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Fraschini, M. G. Bottone, A. I. Scovassi et al., “Changes in extranucleolar transcription during actinomycin D-induced apoptosis,” Histology and Histopathology, vol. 20, no. 1, pp. 107–117, 2005. View at Google Scholar · View at Scopus
  23. S. Cos and E. J. Sanchez-Barcelo, “Melatonin and mammary pathological growth,” Frontiers in Neuroendocrinology, vol. 21, no. 2, pp. 133–170, 2000. View at Publisher · View at Google Scholar
  24. S. M. Hill, L. L. Spriggs, M. A. Simon, H. Muraoka, and D. E. Blask, “The growth inhibitory action of melatonin on human breast cancer cells is linked to the estrogen response system,” Cancer Letters, vol. 64, no. 3, pp. 249–256, 1992. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Belin, A. Beghin, E. Solano-Gonzàlez et al., “Dysregulation of ribosome biogenesis and translational capacity is associated with tumor progression of human breast cancer cells,” PLoS ONE, vol. 4, no. 9, Article ID e7147, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Brandenburger, A. Jenkins, D. J. Autelitano, and R. D. Hannan, “Increased expression of UBF is a critical determinant for rRNA synthesis and hypertrophic growth of cardiac myocytes,” The FASEB Journal, vol. 15, no. 11, pp. 2051–2053, 2001. View at Google Scholar · View at Scopus
  27. V. V. Barygina, V. P. Veiko, and O. V. Zatsepin, “Analysis of nucleolar protein fibrillarin mobility and functional state in living HeLa cells,” Biochemistry, vol. 75, no. 8, pp. 979–988, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. C. Mayer and I. Grummt, “Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases,” Oncogene, vol. 25, no. 48, pp. 6384–6391, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. V. Iadevaia, Y. Huo, Z. Zhang, L. J. Foster, and C. G. Proud, “Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesis,” Biochemical Society Transactions, vol. 40, no. 1, pp. 168–172, 2012. View at Publisher · View at Google Scholar
  30. Y. Gou, Y. Shi, Y. Zhang et al., “Ribosomal protein L6 promotes growth and cell cycle progression through upregulating cyclin E in gastric cancer cells,” Biochemical and Biophysical Research Communications, vol. 393, no. 4, pp. 788–793, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. K. Ghoshal, S. Majumder, J. Datta et al., “Role of human ribosomal RNA (rRNA) promoter methylation and of methyl-CpG-binding protein MBD2 in the suppression of rRNA gene expression,” The Journal of Biological Chemistry, vol. 279, no. 8, pp. 6783–6793, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. J. K. Friedrich, K. I. Panov, P. Cabart, J. Russell, and J. C. B. M. Zomerdijk, “TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter,” The Journal of Biological Chemistry, vol. 280, no. 33, pp. 29551–29558, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Derenzini, D. Trerè, A. Pession, L. Montanaro, V. Sirri, and R. L. Ochs, “Nucleolar function and size in cancer cells,” The American Journal of Pathology, vol. 152, no. 5, pp. 1291–1297, 1998. View at Google Scholar · View at Scopus
  34. L. Golomb, D. R. Bublik, S. Wilder et al., “Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis,” Molecular Cell, vol. 45, no. 2, pp. 222–232, 2012. View at Publisher · View at Google Scholar