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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 893425, 8 pages
Research Article

Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat

1Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran
2Physiology Research Centre, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran
3Department of Pathology, Isfahan University of Medical Sceinces, Isfahan 81745-319, Iran
4Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy, Isfahan University of Medical Sciences, Hezar Jarib Avenue, Isfahan 81745-319, Iran

Received 20 June 2013; Revised 7 September 2013; Accepted 14 September 2013

Academic Editor: Angelo Antonio Izzo

Copyright © 2013 Faraidoon Haghdoost et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The aim of the present study was to evaluate the effect of Pistacia atlantica resin extract on the rat skin burn wound healing. Methods. Thirty-two Wistar rats were divided into four groups and treated by vehicle, 5%, 10%, and 20% concentration of Pistacia atlantica resin extract for 14 days (G1, G2, G3, and G4, resp.). The efficacy of treatment was assessed based on reduction of burn wound size and histological and molecular characteristics. Results. α-Pinene (46.57%) was the main content of essential oil of resin. There were no statistically significant differences between groups according to wound size analysis. The mean histological wound healing scores were not statistically different. Capillary counts of G2 and G3 were significantly higher than those of the G1 ( and 0.032, resp.). NO concentration in wound fluids on the 5th day of study was not significantly different between groups ( ). But bFGF concentration in G2 and G3 and PDGF concentration in G3 were significantly higher in comparison to G1 ( , 0.017, and 0.019, resp.). Conclusion. Our results revealed that Pistacia atlantica resin extract has a concentration-dependent effect on the healing of burn wounds after 14 days of treatment by increasing the concentration of bFGF and PDGF and also through improving the angiogenesis.