Network-Based Biomarkers for Cold Coagulation Blood Stasis Syndrome and the Therapeutic Effects of Shaofu Zhuyu Decoction in Rats

Table 3

The contents of 5-HT, NA, and 𝛽-EP in plasma and brain tissue of model rats and treatment group (𝑛=6,𝑥±𝑠).

	5-HT (ng/mL)		NA (ng/mL)		𝛽-EP (ng/mL)
	Brain tissue	Plasma	Brain tissue	Plasma	Brain tissue	Plasma
Normal group	144.39±30.36	467.71±86.01	3.92±0.72	15.23±2.66	0.28±0.10	2.57±0.45
Model group	259.38±74.48^#	549.9±90.1^#	4.8±1.3^#	18.5±1.9^#	0.15±0.08^#	3.47±1.68^#
SFZYD group (5.4 g kg^−1)	183.49±89.99^∗	492.79±72.14^∗	4.33±1.46	16.95±5.11^∗	0.24±0.09^∗	2.38±1.42^∗
SFZYD group (10.8 g kg^−1)	153.56±76.32^∗∗	458.24±81.56^∗∗	3.85±1.45^∗	15.87±4.36^∗∗	0.34±0.12^∗	2.56±1.89^∗

5-HT: 5-hydroxytryptamine; NA: Noradrenaline; 𝛽-EP: 𝛽-endorphin. Data were expressed as Mean ± SEM. Means between the normal group, model group, low-dose SFZYD-treated group, and high-dose SFZYD-treated group. Significant differences when compared with the model group ^∗𝑃<0.05, ^∗∗𝑃<0.01 and compared with the normal group ^#𝑃<0.05.