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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 906947, 7 pages
Research Article

Comparative Effectiveness of the Deqi Sensation and Non-Deqi by Moxibustion Stimulation: A Multicenter Prospective Cohort Study in the Treatment of Knee Osteoarthritis

1The Affiliated Hospital with Jiangxi University of TCM, Nanchang 330006, China
2Shanxi TCM Hospital, Xian 710003, China
3The First Affiliated Hospital with Anhui University of TCM, Hefei 230031, China
4Jiangsu TCM Hospital, Nanjing 210029, China

Received 10 May 2013; Revised 21 July 2013; Accepted 23 July 2013

Academic Editor: Lin-Peng Wang

Copyright © 2013 Rixin Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Substantial evidence has supported that moxibustion stimulates a unique phenomenon of Deqi, heat-sensitive moxibustion sensation. This study consisted of a multicenter, prospective cohort study with two parallel arms (A: heat-sensitive moxibustion sensation group; B: nonheat-sensitive moxibustion sensation group). All forms of moxibustion were applied unilaterally on the right leg with a triangle shape of three acupuncture points simultaneously (bilateral Xi Yan (EX-LE5) and He Ding (EX-LE2)). After one month the primary outcome parameter GPCRND-KOA showed significant differences between groups: trial group 5.23 ± 2.65 (adjusted mean ± SE) 95% CI [4.44~6.01] versus control group 7.43 ± 2.80 [6.59~8.26], . Significant differences were manifested in total M-JOA score during the follow-up period (). Mean knee circumference indicated significant difference between the groups (; ). Overall, this evidence suggested that the effectiveness of the Deqi sensation group might be more superior than the non-Deqi sensation one in the treatment of KOA. This study was aimed at providing scientific evidence on the Deqi sensation of moxibustion and at showing that heat-sensitive moxibustion sensation is essential to achieve the preferable treatment effects of KOA.