Bioactive Fraction of Geopropolis from Melipona scutellaris Decreases Neutrophils Migration in the Inflammatory Process: Involvement of Nitric Oxide Pathway

Figure 1

Inhibitory effect of the ethanolic extract of geopropolis (EEGP) and aqueous fraction (AF) on neutrophils migration into the peritoneal cavity induced by carrageenan. Neutrophil migration was determined 4 h after the injection of carrageenan 500 μg/cavity. Mice previously treated with vehicle (saline and carrageenan), EEGP (a), hexane fraction (HF-(b)), chloroform (CF-(c)), ethyl acetate (EAF-(d)), or aqueous (AF-(e)). The data are expressed as mean ± SEM, 𝑛=6. Symbols indicate statistical difference (𝑃<0.05, Tukey test). ^#Compared to the saline group; *compared to the carrageenan group.

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