Bioactive Fraction of Geopropolis from Melipona scutellaris Decreases Neutrophils Migration in the Inflammatory Process: Involvement of Nitric Oxide Pathway

Table 1

EEGP effect on carrageenan-induced paw edema on mice.


Treatment (mg/kg)	Time (h) after injection of carrageenan
Treatment (mg/kg)	1	2	3	4	5

Carrageenan	0.06 ± 0.01	0.08 ± 0.01	0.13 ± 0.02	0.16 ± 0.01	0.15 ± 0.01
EEGP 1 mg/kg	0.04 ± 0.01	0.05 ± 0.02	0.06 ± 0.02*	0.11 ± 0.02	0.12 ± 0.02
EEGP 3 mg/kg	0.05 ± 0.01	0.06 ± 0.01	0.05 ± 0.01*	0.12 ± 0.01	0.15 ± 0.01
EEGP 10 mg/kg	0.05 ± 0.01	0.05 ± 0.01	0.05 ± 0.02*	0.12 ± 0.01	0.13 ± 0.01
EEGP 30 mg/kg	0.05 ± 0.01	0.05 ± 0.01	0.05 ± 0.01*	0.06 ± 0.01*	0.05 ± 0.02*

The data are expressed as mean ± SEM, n = 6. Symbols indicate statistical difference (P < 0.05, Tukey test). *Compared to the carrageenan group.