Protective Effects of Huang-Lian-Jie-Du-Tang against Polymicrobial Sepsis Induced by Cecal Ligation and Puncture in Rats
Figure 1
HLJDT protects rats from CLP-induced lethality and ameliorates CLP-induced tissue injuries to livers and lungs. Rats were orally administrated with HLJDT (120 or 270 mg/kg) or vehicle at 2 h prior to CLP or sham surgery. (a) Survival was monitored every 12 h for 108 h after CLP. rats/group, * versus CLP control. (b) Livers and lungs were harvested 24 h after CLP for histopathologic examination using hematoxylin and eosin staining. Representative images from six animals per group were shown. (c) Blood samples were collected 24 h after CLP and ALT and AST levels in plasma were measured. rats/group, * versus CLP control, # versus sham control.
