Flavonoids Identified from Korean Scutellaria baicalensis Georgi Inhibit Inflammatory Signaling by Suppressing Activation of NF-κB and MAPK in RAW 264.7 Cells

Figure 1

(a) High performance liquid chromatography profiles at 280 nm of the polyphenolic extract from Korean Scutellaria baicalensis G.: (1) pentahydroxyflavanone derivative, (2) pentahydroxyflavanone, (3) viscidulin I –O– diglucoside, (4) pentahydroxyflavone, (5) unidentified, (6) viscidulin III–O– glucoside, (7) tetrahydroxyflavone, (8) iridin, (9) eriodictyol (4′-hydroxynaringenin), (10) puerarin, (11) viscidulin III, (12) pentahydroxyflavone, (13) unidentified, (14) baicalin, (15) scutellarein, and (16) isoscutellarein, and (b) the effect of the flavonoids on RAW 264.7 macrophage viability was investigated by MTT assay at various concentrations (10, 40, 70, and 100 μg/mL) in the absence (b) or presence of lipopolysaccharide (1 μg/mL) (b-1).