A Network Pharmacology Approach to Evaluating the Efficacy of Chinese Medicine Using Genome-Wide Transcriptional Expression Data
Figure 4
(a) The regulating score map of MI and SHENMAI and the regulating trend map of SHENMAI. The regulating trends of the original MI network (disease state) and the SHENMAI network were similar but contrary to the regulating trend map of SHENMAI, which indicated that SHENMAI alleviated the disease status but did not severely reverse the biological system. (b) The top 10 up and down regulated genes in the original disease network. As shown, the directions (up or down) of the regulating score (MI and SHENMAI) and regulating trend are different, which means that the SHENMAI treatment more or less recovers these top regulated genes, indicating that SHENMAI could help the biological system recover from the disease state.
