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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 916590, 11 pages
http://dx.doi.org/10.1155/2013/916590
Research Article

Therapeutic Effect of C-Phycocyanin Extracted from Blue Green Algae in a Rat Model of Acute Lung Injury Induced by Lipopolysaccharide

1Department of Intensive Care, Chi Mei Medical Center Liou Ying Campus, Tainan, Taiwan
2Department of Surgery, Chi Mei Medical Center, Liou Ying Campus, Tainan, Taiwan
3Institute of Physiology, National Defense Medical Center, Taipei, Taiwan
4Department of Biomedical Engineering, National Defense Medical Center, Institute of Medical Sciences, Tzu Chi University, 701 Zhongyang Road, Hualien, Taiwan

Received 3 November 2012; Revised 20 February 2013; Accepted 21 February 2013

Academic Editor: Jenny M. Wilkinson

Copyright © 2013 Pak-on Leung et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. E. Erickson, G. S. Martin, J. L. Davis, M. A. Matthay, and M. D. Eisner, “Recent trends in acute lung injury mortality: 1996–2005,” Critical Care Medicine, vol. 37, no. 5, pp. 1574–1579, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Tsushima, L. S. King, and N. R. Aggarwal, “Acute lung injury review,” Internal Medicine, vol. 48, no. 9, pp. 621–631, 2009. View at Publisher · View at Google Scholar
  3. D. Togbe, S. Schnyder-Candrian, B. Schnyder et al., “Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury,” International Journal of Experimental Pathology, vol. 88, no. 6, pp. 387–391, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Chopra, J. S. Reuben, and A. C. Sharma, “Acute lung injury: apoptosis and signaling mechanisms,” Experimental Biology and Medicine, vol. 234, no. 4, pp. 361–371, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Copeland, H. Shaw Warren, S. F. Lowry, S. E. Galvano, and D. Remick, “Acute inflammatory response to endotoxin in mice and humans,” Clinical and Diagnostic Laboratory Immunology, vol. 12, no. 1, pp. 60–67, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Chen, C. Bai, and X. Wang, “The value of the lipopolysaccharide-induced acute lung injury model in respiratory medicine,” Expert Review of Respiratory Medicine, vol. 4, no. 6, pp. 773–783, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. V. B. Bhat and K. M. Madyastha, “C-Phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro,” Biochemical and Biophysical Research Communications, vol. 275, no. 1, pp. 20–25, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. B. B. Vadiraja, N. W. Gaikwad, and K. M. Madyastha, “Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicty in rats,” Biochemical and Biophysical Research Communications, vol. 249, no. 2, pp. 428–431, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. H. F. Chiu, S. P. Yang, Y. L. Kuo, Y. S. Lai, and T. C. Chou, “Mechanisms involved in the antiplatelet effect of C-phycocyanin,” British Journal of Nutrition, vol. 95, no. 2, pp. 434–439, 2006. View at Google Scholar
  10. C. Romay, R. González, N. Ledón, D. Remirez, and V. Rimbau, “C-Phycocyanin: a biliprotein with antioxidant, anti-inflammatory and neuroprotective effects,” Current Protein and Peptide Science, vol. 4, no. 3, pp. 207–216, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. S. C. Cherng, S. N. Cheng, A. Tarn, and T. C. Chou, “Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages,” Life Sciences, vol. 81, no. 19-20, pp. 1431–1435, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J. L. Kang, H. W. Lee, H. S. Lee et al., “Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide,” American Journal of Respiratory and Critical Care Medicine, vol. 164, no. 12, pp. 2206–2212, 2002. View at Google Scholar · View at Scopus
  13. J. H. Yeh, H. F. Chiu, J. S. Wang, J. K. Lee, and T. C. Chou, “Protective effect of baicalein extracted from Scutellaria baicalensis against lipopolysaccharide-induced glomerulonephritis in mice,” International Journal of Pharmacology, vol. 6, no. 2, pp. 81–88, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Xu, X. Gao, J. Xu et al., “Ischemic postconditioning attenuates lung reperfusion injury and reduces systemic proinflammatory cytokine release via heme oxygenase 1,” Journal of Surgical Research, vol. 166, no. 2, pp. e157–e164, 2011. View at Publisher · View at Google Scholar · View at Scopus
  15. P. P. Tak and G. S. Firestein, “NF-κB: a key role in inflammatory diseases,” Journal of Clinical Investigation, vol. 107, no. 1, pp. 7–11, 2001. View at Google Scholar · View at Scopus
  16. W. L. Lee and G. P. Downey, “Neutrophil activation and acute lung injury,” Current Opinion in Critical Care, vol. 7, no. 1, pp. 1–7, 2001. View at Publisher · View at Google Scholar · View at Scopus
  17. R. B. Goodman, J. Pugin, J. S. Lee, and M. A. Matthay, “Cytokine-mediated inflammation in acute lung injury,” Cytokine and Growth Factor Reviews, vol. 14, no. 6, pp. 523–535, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Agouridakis, D. Kyriakou, M. G. Alexandrakis et al., “The predictive role of serum and bronchoalveolar lavage cytokines and adhesion molecules for acute respiratory distress syndrome development and outcome,” Respiratory Research, vol. 3, article 25, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. G. U. Meduri, G. Kohler, S. Headley, E. Tolley, F. Stentz, and A. Postlethwaite, “Inflammatory cytokines in the BAL of patients with ARDS: persistent elevation over time predicts poor outcome,” Chest, vol. 108, no. 5, pp. 1303–1314, 1995. View at Google Scholar · View at Scopus
  20. S. Mehta, “The effects of nitric oxide in acute lung injury,” Vascular Pharmacology, vol. 43, no. 6, pp. 390–403, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. L. F. Wang, M. Patel, H. M. Razavi et al., “Role of inducible nitric oxide synthase in pulmonary microvascular protein leak in murine sepsis,” American Journal of Respiratory and Critical Care Medicine, vol. 165, no. 12, pp. 1634–1639, 2002. View at Publisher · View at Google Scholar · View at Scopus
  22. C. Sittipunt, K. P. Steinberg, J. T. Ruzinski et al., “Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 2, pp. 503–510, 2001. View at Google Scholar · View at Scopus
  23. K. Ejima, M. D. Layne, I. M. Carvajal et al., “Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death,” The FASEB Journal, vol. 17, no. 10, pp. 1325–1327, 2003. View at Google Scholar · View at Scopus
  24. R. Gust, J. K. Kozlowski, A. H. Stephenson, and D. P. Schuster, “Role of cyclooxygenase-2 in oleic acid-induced acute lung injury,” American Journal of Respiratory and Critical Care Medicine, vol. 160, no. 4, pp. 1165–1170, 1999. View at Google Scholar · View at Scopus
  25. Y. C. Xie, X. W. Dong, X. M. Wu, X. F. Yan, and Q. M. Xie, “Inhibitory effects of flavonoids extracted from licorice on lipopolysaccharide-induced acute pulmonary inflammation in mice,” International Immunopharmacology, vol. 9, no. 2, pp. 194–200, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. H. S. Park, S. R. Kim, and Y. C. Lee, “Impact of oxidative stress on lung diseases,” Respirology, vol. 14, no. 1, pp. 27–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Ou, S. Zheng, L. Lin, Q. Jiang, and X. Yang, “Protective effect of C-phycocyanin against carbon tetrachloride-induced hepatocyte damage in vitro and in vivo,” Chemico-Biological Interactions, vol. 185, no. 2, pp. 94–100, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. Berthiaume and M. A. Matthay, “Alveolar edema fluid clearance and acute lung injury,” Respiratory Physiology and Neurobiology, vol. 159, no. 3, pp. 350–359, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. M. J. Morgan and Z. G. Liu, “Crosstalk of reactive oxygen species and NF-κB signaling,” Cell Research, vol. 21, no. 1, pp. 103–115, 2010. View at Google Scholar
  30. J. G. Wright and J. W. Christman, “The role of nuclear factor κB in the pathogenesis of pulmonary diseases: implications for therapy,” American Journal of Respiratory Medicine, vol. 2, no. 3, pp. 211–219, 2003. View at Google Scholar · View at Scopus
  31. A. A. Imanifooladi, S. Yazdani, and M. R. Nourani, “The role of nuclear factor-κB in inflammatory lung disease,” Inflammation and Allergy Drug Targets, vol. 9, no. 3, pp. 197–205, 2010. View at Google Scholar · View at Scopus