Electroacupuncture Could Regulate the NF-𝜿B Signaling Pathway to Ameliorate the Inflammatory Injury in Focal Cerebral Ischemia/Reperfusion Model Rats

Figure 3

Levels of IL-1β and IL-13 in focal ischemic brain tissue and serum of rats among sham, I/R group, EA group, and NBD peptide group at different timepoints (5 rats in each group per time point, total 80 rats). (a) IL-1β levels in the brain of the I/R group increased significantly from 6 h to 48 h which were higher than those in EA group and NBD group, ^∗𝑃<0.05. IL-1β levels in the EA group and NBD peptide group decreased gradually, ^#𝑃<0.05, ^†𝑃<0.05. (b) In serum, IL-1β levels peaked at 48 h in the I/R group and was significantly higher than those in the EA group and NBD group, ^∗𝑃<0.05. ^†𝑃<0.05. IL-1β levels in the EA group decreased gradually even at 12 h, ^#𝑃<0.05. (c) In the brain, IL-13 peaked in the I/R group at 48 h, although these levels were lower than those in the EA group and NBD group, ^∗𝑃<0.05. IL-13 levels peaked in the EA group at 24 h and in the NBD group at 12 h, and 24 h were significantly higher, ^#𝑃<0.05, ^†𝑃<0.05 versus I/R group. (d) There were no significant changes in the serum IL-13 levels in the I/R group at any of the timepoints, and these levels were significantly lower than those in the EA group and NBD group, ^∗𝑃<0.05. The levels in NBD group were higher, ^‡𝑃<0.05 versus EA group^‡.

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