Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 4

Review Article

Effects and Mechanisms of Chinese Herbal Medicine in Ameliorating Myocardial Ischemia-Reperfusion Injury

Table 4

Efficacy and mechanism of patent drugs made up of Chinese herbs in the treatment of MIR.

Mechanism of action in TCM terminologyPatent drug nameMain ingredientMechanismBiomarker/TargetsIn vivo/In vitroReferences

Activating Blood to resolve stasis, and moving Qi to relieve painXinKeShu Tablet Salvia, arrowroot, woody, hawthorn, panaxAntioxidant, promote angiogenesiseNOS; VCAM-1In vivo[113]
TongXinLuo Superfine Ginseng, leeches, scorpion, Eupolyphaga, centipede, et alAntioxidant, proangiogenesisNO, eNOS; vWF, HhcyIn vivo[114]
ShuMai Capsule Peanut shellsPromote angiogenesisvWF, VEGFIn vivo[115]

Moving Qi to activate circulation and relieve painGuanXin ErHao (Guanxin II) Safflower, red peony, salvia, Chuanxiong, and so forthAnti-apoptosis, protect mitochondrial functionCaspase-3, Caspase-9, Bcl-2/Bax, cytochrome c, AktIn vivo[63, 64]
XiongShao Capsule Rhizoma Chuanxiong, Radix Paeoniae RubraAnti-inflammationTNF- , MCP-1, ICIIn vivo[59]

Replenishing Qi to activate circulation, and moving Qi to relieve painVigconic 28 (VI-28) Radix Ginseng, Cornu Cervi, Cordyceps, Radix Salviae, Semen Allii, and so forthAntioxidant, protect mitochondrial functionGSH, -TOC, CuZn-SOD, Ca2+-induced permeability, mitochondrial MDA, Ca2+, cytochrome cIn vivo[116]
Acanthopanax Senticosus Injection AcanthopanaxAntioxidant, inhibit Ca2+ overloadSOD, MDA, GPx; Ca2+In vivo[55]
ShuangShen NingXin Capsule Ginseng total saponins, total salvianolic, corydalisAntioxdiantSOD, MDAIn vivo[117]
ShuangShen TongGuan Recipe Ginseng, astragalus, Atractylodes, and so forthAnti-inflammationNF-κB, p65, TNF- , ICAM-1, MJIC-Cx43In vivo[118]

Replenishing Qi and invigorating Yang ShenFu Injections Red ginseng, MonkshoodAntioxdiant, reduce ME, up-regulate-ATPaseSOD, GPx; LDH, CK; Na+-K+-ATP and Ca2+-ATPIn vivo[119]
Replenishing Blood and activating circulationDanHong Injection Salvia, safflowerAntioxidantSOD, MDAIn vivo [120]
Cardiotonic Pill Salvia miltiorrhizaAnti-apoptosisCaspase-3, AktIn vivo[62]

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