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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 928582, 8 pages
Research Article

Antiobesity Effect of Caraway Extract on Overweight and Obese Women: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial

1Department of Science & Technology Studies, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
2National Nutrition & Food Technology Research Institute, Faculty of Nutrition & Food Technology, Shahid Beheshti University of Medical Sciences, Tehran 1981619573, Iran
3Department of Pharmacology, Faculty of Medicine, University of Malaya, 60302 Kuala Lumpur, Malaysia
4Department of Pharmacology and Toxicology, Pharmacy School, Yazd Shahid Sadoughi Medical Sciences University, Yazd 8917945556, Iran
5Natural Products Inc., Evanston, IL 60203, USA

Received 18 July 2013; Accepted 5 September 2013

Academic Editor: James William Daily III

Copyright © 2013 Mahnaz Kazemipoor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Caraway (Carum carvi L.), a potent medicinal plant, is traditionally used for treating obesity. This study investigates the weight-lowering effects of caraway extract (CE) on physically active, overweight and obese women through a randomized, triple-blind, placebo-controlled clinical trial. Seventy overweight and obese, healthy, aerobic-trained, adult females were randomly assigned to two groups ( per group). Participants received either 30 mL/day of CE or placebo without changing their diet or physical activity. Subjects were examined at baseline and after 90 days for changes in body composition, anthropometric indices, and clinical and paraclinical variables. The treatment group, compared with placebo, showed a significant reduction of weight, body mass index, body fat percentage, and waist-to-hip ratio. No changes were observed in lipid profile, urine-specific gravity, and blood pressure of subjects. The results suggest that a dietary CE with no restriction in food intake, when combined with exercise, is of value in the management of obesity in women wishing to lower their weight, BMI, body fat percentage, and body size, with no clinical side effects. In conclusion, results of this study suggest a possible phytotherapeutic approach for caraway extract in the management of obesity. This trial is registered with NCT01833377.