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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 929074, 8 pages
http://dx.doi.org/10.1155/2013/929074
Research Article

Evaluation of Antidiabetic Activity and Associated Toxicity of Artemisia afra Aqueous Extract in Wistar Rats

Research Center for Phytomedicine, Department of Botany, University of Fort Hare, Alice 5700, South Africa

Received 31 March 2013; Revised 15 May 2013; Accepted 20 May 2013

Academic Editor: Mohamed Eddouks

Copyright © 2013 Taofik O. Sunmonu and Anthony J. Afolayan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. C. Pickup and G. Williams, Epidemiology of Diabetes Mellitus, Blackwell, Oxford, UK, 1997.
  2. S. Wild, G. Roglic, A. Green, R. Sicree, and H. King, “Global prevalence of diabetes: estimates for the year 2000 and projections for 2030,” Diabetes Care, vol. 27, no. 5, pp. 1047–1053, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. D. E. Moller and J. S. Flier, “Insulin resistance—mechanisms, syndromes, and implications,” The New England Journal of Medicine, vol. 325, no. 13, pp. 938–948, 1991. View at Google Scholar · View at Scopus
  4. American Diabetes Association, “Standards of medical care for patients with diabetes mellitus (position statement),” Diabetes Care, vol. 20, no. 1, pp. 518–520, 1997. View at Google Scholar
  5. G. Robinson and D. E. Johnston, Mechanisms of Disease: An Introduction To Clinical Science, Cambridge University Press, Cambridge, Mass, USA, 1st edition, 1997.
  6. B. E. Van Wyk, B. Van Oudtshoorn, and N. Gericke, Medicinal Plants of South Africa, Briza Publications, Pretoria, South Africa, 1997.
  7. C. J. Bailey and C. Day, “Traditional plant medicines as treatments for diabetes,” Diabetes Care, vol. 12, no. 8, pp. 553–564, 1989. View at Google Scholar · View at Scopus
  8. L. Dey, A. S. Attele, and C. Yuan, “Alternative therapies for type 2 diabetes,” Alternative Medicine Review, vol. 7, no. 1, pp. 45–58, 2002. View at Google Scholar · View at Scopus
  9. B. S. Joshi and P. N. Kaul, “Alternative medicine: herbal drugs and their critical appraisal—part I,” Progress in Drug Research, vol. 56, pp. 1–76, 2001. View at Google Scholar · View at Scopus
  10. K. Ravi, K. Sivagnanam, and S. Subramanian, “Anti-diabetic activity of Eugenia jambolana seed kernels on streptozotocin-induced diabetic rats,” Journal of Medicinal Food, vol. 7, no. 2, pp. 187–191, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. R. J. Henry, D. C. Cannon, and J. W. Winkleman, Clinical Chemistry, Principles and Techniques, Harper and Row, London, UK, 2nd edition, 1974.
  12. J. A. Owen, B. Iggo, F. J. Scandrett, and C. P. Stewart, “The determination of creatinine in plasma or serum, and in urine; a critical examination,” The Biochemical Journal, vol. 58, no. 3, pp. 426–437, 1954. View at Google Scholar · View at Scopus
  13. W. H. Marsh, B. Fingerhut, and H. Miller, “Automated and manual direct methods for the determination of blood urea,” Clinical chemistry, vol. 11, pp. 624–627, 1965. View at Google Scholar · View at Scopus
  14. N. W. Tietz, E. L. Prude, and O. Sirgard-Anderson, Tietz Textbook of Clinical Chemistry, WB Saunders Company, London, UK, 1994.
  15. N. W. Tietz, Clinical Guide to laboratory Tests, WB Saunders, Philadelphia, Pa, USA, 3rd edition, 1995.
  16. H. T. Malloy and K. A. Evelyn, “The determination of bilirubin with the photoelectric colorimeter,” The Journal of Biological Chemistry, vol. 119, no. 2, pp. 481–490, 1937. View at Google Scholar
  17. K. Spencer and C. P. Price, “Influence of reagent quality and reaction conditions on the determination of serum albumin by the bromcresol green dye binding method,” Annals of Clinical Biochemistry, vol. 14, no. 2, pp. 105–115, 1977. View at Google Scholar · View at Scopus
  18. P. J. Wright, P. D. Leathwood, and D. T. Plummer, “Enzymes in rat urine: alkaline phosphatase,” Enzymologia, vol. 42, no. 4, pp. 317–327, 1972. View at Google Scholar · View at Scopus
  19. G. Szasz, “A kinetic photometric method for serum gamma-glutamyl transpeptidase,” Clinical Chemistry, vol. 15, no. 2, pp. 124–136, 1969. View at Google Scholar · View at Scopus
  20. E. Schmidt and F. W. Schmidt, “Determination of serum GOT and GPT activities,” Enzymologia Biologica Et Clinica, vol. 3, no. 1, pp. 1–5, 1963. View at Google Scholar
  21. K. L. Joy and R. Kuttan, “Anti-diabetic activity of Picrorrhiza kurroa extract,” Journal of Ethnopharmacology, vol. 67, no. 2, pp. 143–148, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. A. K. Shetty, G. S. Kumar, K. Sambaiah, and P. V. Salimath, “Effect of bitter gourd (Momordica charantia) on glycaemic status in streptozotocin induced diabetic rats,” Plant Foods for Human Nutrition, vol. 60, no. 3, pp. 109–112, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. E. Silbernagel, H. Spreitzer, and G. Buchbauer, “Non-volatile constituents of Artemisia afra,” Monatshefte für Chemie Chemical Monthly, vol. 121, no. 5, pp. 433–436, 1990. View at Publisher · View at Google Scholar · View at Scopus
  24. I. A. Abdel-Hassan, J. A. Abdel-Barry, and S. Tariq Mohammeda, “The hypoglycaemic and antihyperglycaemic effect of Citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits,” Journal of Ethnopharmacology, vol. 71, no. 1-2, pp. 325–330, 2000. View at Publisher · View at Google Scholar · View at Scopus
  25. A. J. Afolayan and T. O. Sunmonu, “Artemisia afra jacq. ameliorates oxidative stress in the pancreas of streptozotocin-induced diabetic wistar rats,” Bioscience, Biotechnology and Biochemistry, vol. 75, no. 11, pp. 2083–2086, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Pari and J. Uma Maheswari, “Antihyperglycemic activity of Musa sapientum flowers: effect on lipid peroxidation in alloxan diabetic rats,” Phytotherapy Research, vol. 14, no. 2, pp. 136–138, 2000. View at Google Scholar
  27. J. Virdi, S. Sivakami, S. Shahani, A. C. Suthar, M. M. Banavalikar, and M. K. Biyani, “Antihyperglycemic effects of three extracts from Momordica charantia,” Journal of Ethnopharmacology, vol. 88, no. 1, pp. 107–111, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. L. Al-Shamaony, S. M. Al-Khazraji, and H. A. A. Twaij, “Hypoglycaemic effect of Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals,” Journal of Ethnopharmacology, vol. 43, no. 3, pp. 167–171, 1994. View at Publisher · View at Google Scholar · View at Scopus
  29. G. G. Rhoads, C. L. Gulbrandsen, and A. Kagan, “Serum lipoproteins and coronary heart disease in a population study of Hawaii Japanese men,” The New England Journal of Medicine, vol. 294, no. 6, pp. 293–298, 1976. View at Google Scholar · View at Scopus
  30. S. Mediene-Benchekor, T. Brousseau, F. Richard et al., “Blood lipid concentrations and risk of myocardial infarction,” The Lancet, vol. 358, no. 9287, pp. 1064–1065, 2001. View at Publisher · View at Google Scholar · View at Scopus
  31. H. B. Brewer Jr., “Hypertriglyceridemia: changes in the plasma lipoproteins associated with an increased risk of cardiovascular disease,” American Journal of Cardiology, vol. 83, no. 9, pp. 3F–12F, 1999. View at Google Scholar · View at Scopus
  32. R. R. Dighe, F. J. Rojas, L. Birnbaumer, and A. J. Garber, “Glucagon-stimulable adenylyl cyclase in rat liver. The impact of streptozotocin-induced diabetes mellitus,” The Journal of Clinical Investigation, vol. 73, no. 4, pp. 1013–1023, 1984. View at Google Scholar · View at Scopus
  33. K. L. Moore and A. F. Dalley, Clinical Oriented Anatomy, Woller Klumner Corporation Philadelphia, 1999.
  34. M. A. Akanji, “Effect of chronic consumption of metabisulphite on the integrity of the rat kidney cellular system,” Toxicology, vol. 81, no. 3, pp. 173–179, 1993. View at Google Scholar · View at Scopus
  35. L. A. Kaplan and A. J. Pesce, Clinical Chemistry: Theory, Analysis and Correlation, Harcourt Health Science Company, London, UK, 1996.
  36. M. T. Yakubu, L. S. Bilbis, M. Lawal, and M. A. Akanji, “Effect of repeated administration of sildenafil citrate on selected enzyme activities of liver and kidney of male albino rats,” Nigerian Journal of Pure Applied Science, vol. 18, no. 1, pp. 1395–1400, 2003. View at Google Scholar
  37. M. F. Rahman, “Effects of vepacide (Azadirachta indica) on aspartate and alanine aminotransferase profiles in a subchronic study with rats,” Human and Experimental Toxicology, vol. 20, no. 5, pp. 243–249, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. P. L. Wolf, D. Williams, T. Tsudaka, and L. Acosta, Methods and Techniques in Clinical Chemistry, John Wiley & Sons, New York, NY, USA, 1972.
  39. N. W. Tietz, Fundamentals of Clinical Chemistry, WB Saunders, Philadelphia, Pa, USA, 1986.
  40. B. Naganna, “Plasma proteinseds,” in Textbook of Biochemistry and Human Biology, G. P. Tawlar, L. M. Srivastava, and K. D. Moudgils, Eds., pp. 172–180, Prentice-Hall, New Delhi, India, 1999. View at Google Scholar
  41. S. Loeb, Clinical Laboratory Test: Values and Implication, Springhouse Corporation, Pa, USA, 1991.
  42. I. A. Ramsey, A Synopsis of Endocrinology and Metabolism, Wright Publisher, Bristol, UK, 1986.
  43. I. J. Atangwho, P. E. Ebong, M. U. Eteng, E. U. Eyong, and A. U. Obi, “NEffect of Vernonia amygdalina del leaf on kidney function of diabetic rats,” International Journal of Pharmacology, vol. 3, no. 2, pp. 143–148, 2007. View at Google Scholar · View at Scopus
  44. A. C. Perez, V. Franca, V. M. Daldegan Jr., and I. D. G. Duarte, “Effect of Solanum lycocarpum St. Hill on various haematological parameters in diabetic rats,” Journal of Ethnopharmacology, vol. 106, no. 3, pp. 442–444, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Talubmook, “Effect of polysaccharide form Phellinus ignarius (L.) Quel. on haematological values and blood cell characteristics in diabetic rats,” Journal of Microscopy Society of Thailand, vol. 22, pp. 42–45, 2008. View at Google Scholar