Topical Administration of Manuka Oil Prevents UV-B Irradiation-Induced Cutaneous Photoaging in Mice
Inhibition of UV-B induced cutaneous photoaging by manuka oil in hairless mice. The dorsal skin surfaces of hairless mice were irradiated by UV-B, 3 times a week for 8 weeks while various concentrations of topical manuka oil were applied every day except Sunday. Each treated group consists of 6 mice. (a) Representative photographs to show the appearance of the dorsal skin area at the end of 8 weeks of the experiment. Increase of skin thickness (b) and wrinkle grade (c) due to repetitive UV-B irradiation and their suppression by manuka oil in a dose-dependent manner. The increases of both skin thickness and wrinkle grade were significantly different between the no UV-B-irradiated control group and the groups treated with 5% and 10% of manuka oil ().