Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor γ Activation
Figure 1
Antiproliferative effects of DMC in breast cancer cells. (a) The chemical structure of 3β,7β-dihydroxy-25-methoxycucurbita-5,23-diene-19-al (DMC). (b) Dose- and time-dependent suppressive effects of DMC on the viability of MCF-7 breast cancer cells. (c) Dose- and Time-dependent suppressive effects of DMC on the viability of MDA-MB-231 breast cancer cells. Cells were treated with DMC at indicated concentrations in 5% FBS-supplemented DMEM/F12 medium for 24, 48, and 72 h, and cell viability was determined by MTT assays. Points, mean; bars, SD (). .
