Cucurbitane Triterpenoid from Momordica charantia Induces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated Receptor γ Activation
Figure 6
Effects of chloroquine (CQ) on DMC-induced autophagy and cytotoxicity. (a) Effects of 15 μM DMC, 10 μM chloroquine, or the drug combination relative to DMSO control in MCF-7 cells after 72 h exposure in 5% FBS-DMEM/F12. (b) MCF-7 cells were treated with chloroquine (CQ) alone (right panel) or in combination with DMC at indicated concentrations (left panel) for 72 h, and cell viability was determined by MTT assays. Points, mean; bars, SD (). . (c) MCF-7 cells were treated with DMSO or DMC (15 μM) alone or in combination with 10 μM chloroquine (CQ) for 72 h exposure in 5% FBS-DMEM/F12, followed by Annexin V-propidium iodide staining. Data are representative of three independent experiments.
