Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 936257, 10 pages
http://dx.doi.org/10.1155/2013/936257
Research Article

Saussurea lappa Clarke-Derived Costunolide Prevents TNFα-Induced Breast Cancer Cell Migration and Invasion by Inhibiting NF-κB Activity

Laboratory of Clinical Biology and Pharmacogenomics, Center for Clinical Research and Genomics, Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Seoul 130-701, Republic of Korea

Received 5 April 2013; Accepted 3 May 2013

Academic Editor: Bo-Hyoung Jang

Copyright © 2013 Youn Kyung Choi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Sariego, “Breast cancer in the young patient,” The American Surgeon, vol. 76, no. 12, pp. 1397–1400, 2010. View at Google Scholar · View at Scopus
  2. K. I. Block, C. Gyllenhaal, D. Tripathy et al., “Survival impact of integrative cancer care in advanced metastatic breast cancer,” Breast Journal, vol. 15, no. 4, pp. 357–366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. P. A. C. Greenberg, G. N. Hortobagyi, T. L. Smith, L. D. Ziegler, D. K. Frye, and A. U. Buzdar, “Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer,” Journal of Clinical Oncology, vol. 14, no. 8, pp. 2197–2205, 1996. View at Google Scholar · View at Scopus
  4. E.-F. Solomayer, I. J. Diel, G. C. Meyberg, C. Gollan, and G. Bastert, “Metastatic breast cancer: clinical course, prognosis and therapy related to the first site of metastasis,” Breast Cancer Research and Treatment, vol. 59, no. 3, pp. 271–278, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Hanahan and R. A. Weinberg, “The hallmarks of cancer,” Cell, vol. 100, no. 1, pp. 57–70, 2000. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Pantel and R. H. Brakenhoff, “Dissecting the metastatic cascade,” Nature Reviews Cancer, vol. 4, no. 6, pp. 448–456, 2004. View at Google Scholar · View at Scopus
  7. P. S. Steeg, “Tumor metastasis: mechanistic insights and clinical challenges,” Nature Medicine, vol. 12, no. 8, pp. 895–904, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. R. O. Hynes, “Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants: or both?” Cell, vol. 113, no. 7, pp. 821–823, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. Y. Kang, P. M. Siegel, W. Shu et al., “A multigenic program mediating breast cancer metastasis to bone,” Cancer Cell, vol. 3, no. 6, pp. 537–549, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. A. J. Minn, G. P. Gupta, P. M. Siegel et al., “Genes that mediate breast cancer metastasis to lung,” Nature, vol. 436, no. 7050, pp. 518–524, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. F. Balkwill, “Tumor necrosis factor or tumor promoting factor?” Cytokine and Growth Factor Reviews, vol. 13, no. 2, pp. 135–141, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. M. S. Naylor, G. W. H. Stamp, W. D. Foulkes, D. Eccles, and F. R. Balkwill, “Tumor necrosis factor and its receptors in human ovarian cancer: potential role in disease progression,” Journal of Clinical Investigation, vol. 91, no. 5, pp. 2194–2206, 1993. View at Google Scholar · View at Scopus
  13. T. Hehlgans and K. Pfeffer, “The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games,” Immunology, vol. 115, no. 1, pp. 1–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  14. E. E. Varfolomeev and A. Ashkenazi, “Tumor necrosis factor: an apoptosis JuNKie?” Cell, vol. 116, no. 4, pp. 491–497, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Shishodia and B. B. Aggarwal, “Nuclear factor-κB activation: a question of life or death,” Journal of Biochemistry and Molecular Biology, vol. 35, no. 1, pp. 28–40, 2002. View at Google Scholar · View at Scopus
  16. M. K. Pandey, B. Sung, A. B. Kunnumakkara, G. Sethi, M. M. Chaturvedi, and B. B. Aggarwal, “Berberine modifies cysteine 179 of IκBα kinase, suppresses nuclear factor-κB-regulated antiapoptotic gene products, and potentiates apoptosis,” Cancer Research, vol. 68, no. 13, pp. 5370–5379, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. G. Helbig, K. W. Christopherson, P. Bhat-Nakshatri et al., “NF-κB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4,” Journal of Biological Chemistry, vol. 278, no. 24, pp. 21631–21638, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Ghosh, M. J. May, and E. B. Kopp, “NF-κB and rel proteins: evolutionarily conserved mediators of immune responses,” Annual Review of Immunology, vol. 16, pp. 225–260, 1998. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Janssens, A. Tinel, S. Lippens, and J. Tschopp, “PIDD Mediates NF-κB activation in response to DNA damage,” Cell, vol. 123, no. 6, pp. 1079–1092, 2005. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Balkwill, “TNF-α in promotion and progression of cancer,” Cancer and Metastasis Reviews, vol. 25, no. 3, pp. 409–416, 2006. View at Publisher · View at Google Scholar · View at Scopus
  21. H. Häcker and M. Karin, “Regulation and function of IKK and IKK-related kinases,” Science's STKE, vol. 2006, no. 357, p. re13, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. S. G. Ko, H.-P. Kim, D.-H. Jin et al., “Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells,” Cancer Letters, vol. 220, no. 1, pp. 11–19, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. S.-G. Ko, S.-H. Koh, C.-Y. Jun, C.-G. Nam, H.-S. Bae, and M.-K. Shin, “Induction of apoptosis by Saussurea lappa and Pharbitis nil on AGS gastric cancer cells,” Biological and Pharmaceutical Bulletin, vol. 27, no. 10, pp. 1604–1610, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. A. Robinson, T. V. Kumar, E. Sreedhar et al., “A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study,” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 14, pp. 4015–4017, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. C. A. L. Kassuya, A. Cremoneze, L. F. L. Barros et al., “Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae),” Journal of Ethnopharmacology, vol. 124, no. 3, pp. 369–376, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. H.-C. Chen, C.-K. Chou, S.-D. Lee, J.-C. Wang, and S.-F. Yeh, “Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells,” Antiviral Research, vol. 27, no. 1-2, pp. 99–109, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. D. E. Wedge, J. C. G. Galindo, and F. A. Macías, “Fungicidal activity of natural and synthetic sesquiterpene lactone analogs,” Phytochemistry, vol. 53, no. 7, pp. 747–757, 2000. View at Publisher · View at Google Scholar · View at Scopus
  28. C.-N. Chen, H.-H. Huang, C.-L. Wu et al., “Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells,” Cancer Letters, vol. 246, no. 1-2, pp. 237–252, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. H. Mori, T. Kawamori, T. Tanaka, M. Ohnishi, and J. Yamahara, “Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats,” Cancer Letters, vol. 83, no. 1-2, pp. 171–175, 1994. View at Publisher · View at Google Scholar · View at Scopus
  30. J.-H. Choi, J. Ha, J.-H. Park et al., “Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols,” Japanese Journal of Cancer Research, vol. 93, no. 12, pp. 1327–1333, 2002. View at Google Scholar · View at Scopus
  31. J.-L. Hsu, S.-L. Pan, Y.-F. Ho, T.-L. Hwang, F.-L. Kung, and J.-H. Guh, “Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer,” Journal of Urology, vol. 185, no. 5, pp. 1967–1974, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. K. Choi, H. S. Seo, H. S. Choi et al., “Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231,” Molecular and Cellular Biochemistry, vol. 363, no. 1-2, pp. 119–128, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. P. Nyberg, T. Salo, and R. Kalluri, “Tumor microenvironment and angiogenesis,” Frontiers in Bioscience, vol. 13, no. 17, pp. 6537–6553, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. C. M. Overall and C. López-Otín, “Strategies for MMP inhibition in cancer: innovations for the post-trial era,” Nature Reviews Cancer, vol. 2, no. 9, pp. 657–672, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. L. M. Coussens and Z. Werb, “Matrix metalloproteinases and the development of cancer,” Chemistry and Biology, vol. 3, no. 11, pp. 895–904, 1996. View at Google Scholar · View at Scopus
  36. E. I. Deryugina, A. Zijlstra, J. J. Partridge et al., “Unexpected effect of matrix metalloproteinase down-regulation on vascular intravasation and metastasis of human fibrosarcoma cells selected in vivo for high rates of dissemination,” Cancer Research, vol. 65, no. 23, pp. 10959–10969, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. M. E. Kupferman, M. E. Fini, W. J. Muller, R. Weber, Y. Cheng, and R. J. Muschel, “Matrix metalloproteinase 9 promoter activity is induced coincident with invasion during tumor progression,” The American Journal of Pathology, vol. 157, no. 6, pp. 1777–1783, 2000. View at Google Scholar · View at Scopus
  38. I. Stamenkovic, “Matrix metalloproteinases in tumor invasion and metastasis,” Seminars in Cancer Biology, vol. 10, no. 6, pp. 415–433, 2000. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Egeblad and Z. Werb, “New functions for the matrix metalloproteinases in cancer progression,” Nature Reviews Cancer, vol. 2, no. 3, pp. 161–174, 2002. View at Google Scholar · View at Scopus
  40. H. Sato and M. Seiki, “Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells,” Oncogene, vol. 8, no. 2, pp. 395–405, 1993. View at Google Scholar · View at Scopus