The Effect of Chinese Herbal Medicine on Albuminuria Levels in Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis

Table 1

Characteristics of the 29 studies included in the meta-analysis.

Author (s), year	Patients included	Men (%)	Age (years)	Albuminuria	Interventions		Treatment duration	Jadad score
					Experimental	Control
Ma et al., 2011 [12]	409	45	56.6	Microalb; Macroalb	Arctiin granule (TID)	Placebo (TID)	8 weeks	5
Chen, 2010 [13]	60	45	60.5	Microalb; Macroalb	Anshen yin (TID)	Losartan (50 mg/d, QD)	12 weeks	2
Xu, 2005 [14]	64	62.5	56.2	Microalb	Baoshen tang (TID)	Benazepril (5–10 mg/d, QD)	12 weeks	2
Luo, 2008 [15]	72	54.2	56.8	Microalb	Bushen Huoxue decoction (BID)	Benazepril (10 mg/d, QD)	12 weeks	3
Huang and Xu, 2008 [16]	68	54.4	58.0	Microalb	Tangluo Tongshui decoction (BID)	Losartan (50 mg/d, QD)	8 weeks	2
Ge et al., 2010 [17]	55	56.9	51.5	Macroalb	Tripterygium glycosides (120 mg/d, TID)	Valsartan (160 mg/d, QD)	24 weeks	3
Xue and Bai, 2008 [18]	60	55.0	NA	Microalb	Liuwei Dihuang tang (BID)	Losartan (100 mg/d, QD)	12 weeks	2
Zhang, 2012 [19]	70	54.3	62.4	Microalb	Pishen Shuangbu tang (BID)	Benazepril (10 mg/d, QD)	4 weeks	2
Huang, 2011 [20]	70	52.9	56.0	Microalb	Shen an decoction (BID)	Captopril (37.5 mg/d, TID)	8 weeks	2
Zhang et al., 2011 [21]	227	NA	NA	Microalb; Macroalb	Tangshen Kang capsule (TID)	Enalapril (10 mg/d, BID)	8 weeks	3
Huang, 2012 [22]	80	61.3	53.1	Macroalb	Wenshen Jianpi Huoxue tang (BID)	Benazepril (10 mg/d, QD)	8 weeks	2
Dong et al., 2007 [23]	68	57.4	55.0	Microalb	Yiqi Huoxue tang (BID)	Valsartan (80 mg/d, QD)	8 weeks	2
Zhou et al., 2009 [24]	109	38.5	54.8	Microalb	Tangshen decoction (BID)	Losartan (50 mg/d, QD)	12 weeks	3
Wang et al., 2012 [25]	75	51.3	57.2	Microalb	Yiqi Yangyin Xiaozheng Tongluo decoction (BID)	Irbesartan (150 mg/d, QD)	48 weeks	3
Zhong et al., 2012 [26]	100	53.0	48.0	Macroalb	Ziyin Zhuyang Digui tang (BID)	Benazepril (10 mg/d, QD)	12 weeks	2
Chen and Wan, 2011 [27]	62	48.4	61.6	Microalb	Qishen Yiqi drop pill (TID); Enalapril (10 mg/d, QD)	Enalapril (10 mg/d, QD)	8 weeks	2
Wei et al., 2010 [28]	60	55.0	NA	Microalb	Fufang Danpi decoction (BID); Benazepril (10 mg/d, QD)	Benazepril (10 mg/d, QD)	8 weeks	2
Feng et al., 2005 [29]	60	63.3	54.8	Microalb	Kangshen tang (BID); Benazepril (10 mg/d, QD)	Benazepril (10 mg/d, QD)	12 weeks	2
Zhu et al., 2004 [30]	42	50.0	54.8	Microalb	Pingxiao Gujing tang (BID); Benazepril (10 mg/d, QD)	Benazepril (10 mg/d, QD)	8 weeks	2
Li et al., 2006 [31]	81	49.4	50.7	Microalb	Tangshen ling decoction (BID); Telmisartan (80 mg/d, QD)	Telmisartan (80 mg/d, QD)	8 weeks	2
Pan and Xue, 2009 [32]	81	46.6	54.4	Microalb	Tangshen tang (BID); Valsartan (80 mg/d, QD)	Valsartan (80 mg/d, QD)	8 weeks	3
Gong and Wang, 2004 [33]	80	53.8	59.0	Microalb	Yangyin Yiqi decoction (BID); benazepril (10 mg/d, QD)	Benazepril (10 mg/d, QD)	8 weeks	2
Cai et al., 2012 [34]	63	63.5	41.7	Microalb	Yiqi Yangyin Huazhuo Tongluo; decoction (BID); Benazepril (10 mg/d, QD)	Benazepril (10 mg/d, QD)	8 weeks	3
Qu, 2012 [35]	68	55.9	62.4	Microalb	Chunze tang (BID); Benazepril (10 mg/d, QD)	Benazepril (10 mg/d, QD)	2 weeks	2
Li, 2004 [36]	40	45.0	51.8	Microalb	Modified Liuwei Dihuang tang (BID); Enalapril (10 mg/d, QD)	Enalapril (10 mg/d, QD)	12 weeks	2
Wu and Zhang, 2005 [37]	60	43.3	59.0	Microalb	Tangshen kang (BID); Fosinopril (10 mg/d, QD)	Fosinopril (10 mg/d, QD)	8 weeks	2
Chen and Huang, 2006 [38]	60	NA	NA	Microalb	Wuchong tang (BID); Benazepril (10 mg/d, QD)	Benazepril (10 mg/d, QD)	8 weeks	3
Fallahzadeh et al., 2012 [39]	56	46.7	56.8	Macroalb	Silymarin (520 mg/d, TID); ACEI/ARB	Placebo (TID); ACEI/ARB	12 weeks	5
Khajehdehi et al., 2011 [40]	40	55	52.8	Macroalb	Turmeric (1500 mg/d, TID); ACEI/ARB	Placebo (TID); ACEI/ARB	8 weeks	4

Microalb: microalbuminuria; Macroalb: Macroalbuminuria; QD: once a day; BID: twice a day; TID: three times a day. NA: not applicable.