Trypanocidal Activity of Thioamide-Substituted Imidazoquinolinone: Electrochemical Properties and Biological Effects

Table 1

Values of IC₅₀ for the activity of the imidazoquinolinones on epi-, trypo-, and amastigotes forms of Trypanosoma cruzi.

Compound	Epimastigotes		Trypomastigotes		Amastigotes
	IC50 (𝜇M)	SI	IC50 (𝜇M)	SI	IC50 (𝜇M)	SI
C1	1.49±0.28	>67.1	34.89±1.20	>2.9	1.74±0.30	>57.5
C2	5.57±0.53	>18.0	306±15	>0.3	3.63±0.51	>27.5
C3	1.50±0.30	>66.7	246±18	>0.4	1.50±0.32	>66.7
D	>25	ND	≫300	ND	11.44±1.21	ND
Bnz	5.49±0.89	15.1	30.26±2.85	2.7	ND	ND

IC₅₀ and SI values were calculated as indicated in Section 2. ND: not determined.