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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 947980, 6 pages
Research Article

Brazilian Green Propolis Compared to Miconazole Gel in the Treatment of Candida-Associated Denture Stomatitis

1Oral Pathology Laboratory and Stomatology, Dentistry Department, Pontifícia Universidade Católica de Minas Gerais, Dom José Gaspar Avenida, 500, 30535-901 Belo Horizonte, MG, Brazil
2DDS Private Practice in Dentistry, Brazil
3Microbiology Laboratory, Dentistry Departament, Pontifícia Universidade Católica de Minas Gerais, Brazil
4Researcher of FUNED (Fundação Ezequiel Dias) of Minas Gerais, Brazil

Received 3 December 2012; Accepted 3 April 2013

Academic Editor: Zenon Czuba

Copyright © 2013 Hermínia Marques Capistrano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. To evaluate the efficacy of Brazilian green propolis in comparison to miconazole gel in the treatment of Candida-associated denture stomatitis. Methods. Forty-five denture stomatitis patients, with palatal mucosa erythema levels classified according to Newtons’s criteria and with positive culture to Candida spp., were randomly divided into three treatment groups: 15 received miconazole gel 2%, 15 received propolis gel 2,5%, and 15 received propolis 24% for mouthwash. After four daily use lasting two weeks, they were reexamined for the denture stomatitis degree and for a second culture of Candida. The Wilcoxon’s test was applied to compare the results of clinical classification of the denture stomatitis and the Candida spp. colonies numbers, before and after each treatment. The Kruskall-Wallis’s test was used to compare efficacy among the three treatment groups. Results. There were a significant reduction or complete remission of denture stomatitis and a significant decrease of Candida colonies for the three groups There was no difference in the efficacy among the treatment groups . Conclusion. Brazilian green propolis has a similar effect as miconazole in the treatment of Candida-associated denture stomatitis being an alternative in the therapeutics of this condition.