Research Article

Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs

Figure 6

Mechanisms of resensitizing TRAIL-resistant HCC cells by periplocin. Periplocin can resensitize TRAIL resistant HCC by inducing the expression of DR4. Therefore, the combination treatments of TRAIL and periplocin can induce cell apoptosis through direct activation of caspase signaling and indirect inhibition of IAPs.
958025.fig.006