Evidence-Based Complementary and Alternative Medicine / 2013 / Article / Tab 3

Research Article

Antioxidant Capacity, Cytotoxicity, and Acute Oral Toxicity of Gynura bicolor

Table 3

Cytotoxic activity (IC50 values) of G. bicolor extracts against selected human cell lines.

Extract Treatment
duration (hour)
Cytotoxicity (IC50) in g/mL
HT-29HCT 116HCT-15SW480Caco-2MCF7CCD-18Co

Methanol24>100>100>100>100>100>100>100
48>100>100>100>100>100>100>100
72>100>100>100>100>100>100>100

Hexane24>100>100>100>100>100>100>100
48>100>100>100>100>100>100>100
72>100>100>100>100>100>100>100

Ethyl acetate2439.7 ± 1.716.0 ± 4.512.8 ± 5.326.3 ± 1.232.7 ± 1.536.5 ± 3.4>100
4849.5 ± 8.620.9 ± 0.218.7 ± 1.931.7 ± 5.746.3 ± 8.734.8 ± 0.8>100
7237.3 ± 2.529.2 ± 0.921.2 ± 1.247.8 ± 3.655.2 ± 6.446.3 ± 4.2>100

Water24>100>100>100>100>100>100>100
48>100>100>100>100>100>100>100
72>100>100>100>100>100>100>100

Cis-platin*24>12.512.0 ± 0.76.2 ± 0.4>12.5>12.511.2 ± 0.5>12.5
4810.1 ± 0.24.0 ± 0.33.9 ± 0.26.8 ± 0.54.3 ± 0.44.2 ± 0.4>12.5
726.4 ± 0.62.9 ± 0.11.7 ± 0.43.2 ± 0.61.9 ± 0.22.7 ± 0.3>12.5

Positive reference standard. Values are expressed as mean ± standard deviation ( ).

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