Dissection of Mechanisms of a Chinese Medicinal Formula: Danhong Injection Therapy for Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro

Figure 5

DHI and its major active ingredients upregulated expression of phospho-Akt (a) and phospho-ERK1/2 (b) in cardiomyocytes exposed to SI/R. SI/R, simulated ischemia/reperfusion; A, hydroxysafflor yellow A; B, salvianolic acid B; C, danshensu; DHI, Danhong injection; W, wortmannin; U, U0126. Data obtained from quantitative densitometry are presented as mean ± SD of 3 independent experiments. *𝑃<0.05, **𝑃<0.01 versus SI/R.

(a)

(b)