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Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 972370, 12 pages
http://dx.doi.org/10.1155/2013/972370
Research Article

Dissection of Mechanisms of a Chinese Medicinal Formula: Danhong Injection Therapy for Myocardial Ischemia/Reperfusion Injury In Vivo and In Vitro

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China

Received 16 December 2012; Revised 4 April 2013; Accepted 11 April 2013

Academic Editor: Mei Tian

Copyright © 2013 Yue Guan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. M. Yellon and D. J. Hausenloy, “Myocardial reperfusion injury,” New England Journal of Medicine, vol. 357, no. 11, pp. 1074–1135, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. D. J. Hausenloy and D. M. Yellon, “New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway,” Cardiovascular Research, vol. 61, no. 3, pp. 448–460, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Matsumura, R. W. Jeremy, J. Schaper, and L. C. Becker, “Progression of myocardial necrosis during reperfusion of ischemic myocardium,” Circulation, vol. 97, no. 8, pp. 795–804, 1998. View at Google Scholar · View at Scopus
  4. J. Li, H. Zhang, and C. Zhang, “Role of inflammation in the regulation of coronary blood flow in ischemia and reperfusion: mechanisms and therapeutic implications,” Journal of Molecular and Cellular Cardiology, vol. 52, no. 4, pp. 865–872, 2012. View at Publisher · View at Google Scholar
  5. R. A. Gottlieb, “Cell death pathways in acute ischemia/reperfusion injury,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 16, no. 3-4, pp. 233–238, 2011. View at Publisher · View at Google Scholar
  6. J. R. Koenitzer and B. A. Freeman, “Redox signaling in inflammation: Interactions of endogenous electrophiles and mitochondria in cardiovascular disease,” Annals of the New York Academy of Sciences, vol. 1203, pp. 45–52, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. S. V. Lakshmi, G. Padmaja, P. Kuppusamy, and V. K. Kutala, “Oxidative stress in cardiovascular disease,” Indian Journal of Biochemistry & Biophysics, vol. 46, no. 6, pp. 421–440, 2009. View at Google Scholar
  8. S. F. Liou, H. J. Ke, J. H. Hsu et al., “San-Huang-Xie-Xin-Tang prevents rat hearts from ischemia/reperfusion-induced apoptosis through eNOS and MAPK pathways,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 915051, 9 pages, 2011. View at Publisher · View at Google Scholar
  9. T. W. Corson and C. M. Crews, “Molecular understanding and modern application of traditional medicines: triumphs and trials,” Cell, vol. 130, no. 5, pp. 769–774, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. A. D. W. Boran and R. Iyengar, “Systems approaches to polypharmacology and drug discovery,” Current Opinion in Drug Discovery and Development, vol. 13, no. 3, pp. 297–309, 2010. View at Google Scholar · View at Scopus
  11. M. Sun, J. J. Zhang, J. Z. Shan et al., “Clinical observation of Danhong Injection (herbal TCM product from Radix Salviae miltiorrhizae and Flos Carthami tinctorii) in the treatment of traumatic intracranial hematoma,” Phytomedicine, vol. 16, no. 8, pp. 683–689, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Jin, H. Yu, and H. Y. Chen, “Clinical effect of Danhong injection in 40 patients with vascular dementia,” Journal of Traditional Chinese Medicine, vol. 8, pp. 198–200, 2010. View at Google Scholar
  13. L. Chang, K. De, and W. Yan-sheng, “Clinical research of Danhong injection for amelioration of microcirculation in patients with unstable angina,” Clinical Journal of Medical Officers, vol. 36, no. 3, pp. 402–404, 2008. View at Google Scholar
  14. H. Chen, S. H. Zhang, J. Yuan, and Y. L. Wu, “The clinical efficacy of Danhong injection for unstable angina,” International Medicine & Health Guidance News, vol. 18, no. 19, pp. 2883–2885, 2012. View at Google Scholar
  15. L. Hong, “Danhong injection effects on vascular endothelial function in patients undergoing coronary artery stent implantation,” Journal of Clinical Rehabilitative Tissue Engineering Research, vol. 14, no. 13, pp. 2467–2470, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. K. Fan and Q. Wu, “20 cases of Danhong injection in the treatment of thromboangiitis obliterans,” Journal of Emergency in Traditional Chinese Medicine, vol. 19, no. 9, pp. 1624–1625, 2010. View at Google Scholar
  17. P. G. He and D. Ding, “Securities research report of Guosen”.
  18. M. Xie, T. S. Wang, D. L. Wu, and R. H. Zhao, “Cardioprotective effect of the compound yangshen granule in rat models with acute myocardial infarction,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 717123, 6 pages, 2012. View at Publisher · View at Google Scholar
  19. T. L. Yue, C. Wang, J. L. Gu et al., “Inhibition of extracellular signal-regulated kinase enhances ischemia/reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerates reperfusion injury in isolated perfused heart,” Circulation Research, vol. 86, no. 6, pp. 692–699, 2000. View at Google Scholar · View at Scopus
  20. F. Gao, E. Gao, T. L. Yue et al., “Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation,” Circulation, vol. 105, no. 12, pp. 1497–1502, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Stanciu, Y. Wang, R. Kentor et al., “Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures,” Journal of Biological Chemistry, vol. 275, no. 16, pp. 12200–12206, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. K. S. Ahn and B. B. Aggarwal, “Transcription factor NF-kappaB: a sensor for smoke and stress signals,” Annals of the New York Academy of Sciences, vol. 1056, pp. 218–233, 2005. View at Publisher · View at Google Scholar
  23. F. Qin, Y. X. Liu, H. W. Zhao, X. Huang, P. Ren, and Z. Y. Zhu, “Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats,” Phytomedicine, vol. 16, no. 2-3, pp. 215–221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. Y. Yin, Y. Guan, J. L. Duan et al., “Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation,” European Journal of Pharmacology, vol. 699, no. 1–3, pp. 219–226, 2013. View at Publisher · View at Google Scholar
  25. J. M. Luo, X. Xiao, Q. L. Liang, G. A. Luo, and Y. M. Wang, “Fingerprint chromatography of Danhong injection by HPLC,” Chinese Traditional Patent Medicine, vol. 33, no. 8, pp. 1277–1280, 2011. View at Google Scholar
  26. J. Y. Han, J. Y. Fan, Y. Horie et al., “Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion,” Pharmacology and Therapeutics, vol. 117, no. 2, pp. 280–295, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. Z. Broskova, K. Drabikova, R. Sotnikova, S. Fialova, and V. Knezl, “Effect of plant polyphenols on ischemia-reperfusion injury of the isolated rat heart and vessels,” Phytotherapy Research, 2013. View at Publisher · View at Google Scholar
  28. H. Zhou, S. Z. Hou, P. Luo et al., “Ginseng protects rodent hearts from acute myocardial ischemia-reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism,” Journal of Ethnopharmacology, vol. 135, no. 2, pp. 287–298, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. R. F. Gillum, S. P. Fortmann, R. J. Prineas, and T. E. Kottke, “International diagnostic criteria for acute myocardial infarction and acute stroke,” American Heart Journal, vol. 108, no. 1, pp. 150–158, 1984. View at Google Scholar · View at Scopus
  30. D. W. Kehl, N. Iqbal, A. Fard, B. A. Kipper, L. A. de la Parra, and A. S. Maisel, “Biomarkers in acute myocardial injury,” Translational Research, vol. 159, no. 4, pp. 252–264, 2012. View at Publisher · View at Google Scholar
  31. X. Wang, Y. Yu, L. Ji, X. Liang, T. Zhang, and C. X. Hai, “Alpha-lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects,” Food and Chemical Toxicology, vol. 49, no. 11, pp. 2750–2757, 2011. View at Publisher · View at Google Scholar
  32. Y. Zhang, Q. Sun, B. He, J. Xiao, Z. Wang, and X. Sun, “Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion,” International Journal of Cardiology, vol. 148, no. 1, pp. 91–95, 2011. View at Publisher · View at Google Scholar
  33. C. Li, Y. Gao, Y. Xing, H. Zhu, J. Shen, and J. Tian, “Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia-reperfusion injury in rats via regulating the inflammation response,” Food and Chemical Toxicology, vol. 49, no. 9, pp. 2090–2095, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Tuntipopipat, C. Muangnoi, P. Chingsuwanrote et al., “Anti-inflammatory activities of red curry paste extract on lipopolysaccharide-activated murine macrophage cell line,” Nutrition, vol. 27, no. 4, pp. 479–487, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. C. H. Y. Wong and P. J. Crack, “Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury,” Current Medicinal Chemistry, vol. 15, no. 1, pp. 1–14, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. K. S. Bora and A. Sharma, “Evaluation of antioxidant and cerebroprotective effect of Medicago sativa Linn. against ischemia and reperfusion insult,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 792167, 9 pages, 2011. View at Publisher · View at Google Scholar
  37. D. F. Dai, P. S. Rabinovitch, and Z. Ungvari, “Mitochondria and cardiovascular aging,” Circulation Research, vol. 110, no. 8, pp. 1109–1124, 2012. View at Publisher · View at Google Scholar
  38. R. Aikawa, Y. Nitta-Komatsubara, S. Kudoh et al., “Reactive oxygen species induce cardiomyocyte apoptosis partly through TNF-α,” Cytokine, vol. 18, no. 4, pp. 179–183, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. R. von Harsdorf, P. F. Li, and R. Dietz, “Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis,” Circulation, vol. 99, no. 22, pp. 2934–2941, 1999. View at Google Scholar · View at Scopus
  40. D. J. Hausenloy and D. M. Yellon, “Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection,” Heart Failure Reviews, vol. 12, no. 3-4, pp. 217–234, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. B. Ibanez, V. Fuster, J. Jiménez-Borreguero, and J. J. Badimon, “Lethal myocardial reperfusion injury: a necessary evil?” International Journal of Cardiology, vol. 151, no. 1, pp. 3–11, 2011. View at Publisher · View at Google Scholar · View at Scopus