Identification of Immunomodulatory Signatures Induced by American Ginseng in Murine Immune Cells

Table 2

Common gene expression changes induced by two different types of American ginseng products in murine splenic cells ex vivo.

Gene symbol	Fold-change induced by CX	Fold-change induced by CP	Gene symbol	Fold-change induced by CX	Fold-change induced by CP
Aicda	−2.9	−3.1	Ruvbl2	−2.1	−3.2
Ankrd37	−3.2	−2.8	Scd2	−3.3	−3.2
Apitd1	−2.1	−2.3	Sco1	−2.7	−4.0
Asf1b	−2.1	−3.4	Serpina3f	−24.3	−12.5
Atf3	−4.1	−3.1	Serpina3g	−10.2	−5.8
Auh	−2.2	−2.1	Sgol2	−2.3	−3.4
Aurkb	−2.4	−4.8	Siah2	−2.3	−3.1
Birc5	−2.2	−5.4	St6galnac4	−2.1	−2.2
Brip1	−2.2	−2.7	Stat1	−3.0	−2.7
Brrn1	−2.3	−3.9	Tbx21	−6.7	−5.6
Car13	−2.1	−2.4	Tcf19	−2.3	−3.2
Ccdc99	−2.3	−2.5	Tg	−2.7	−3.8
Ccnd2	−2.4	−2.4	Tmem97	−2.0	−3.0
Ccne1	−3.0	−2.9	Top2a	−2.0	−3.4
Ccr5	−3.1	−3.1	Tpi1	−2.9	−3.7
Cd86	−2.8	−2.1	Tpx2	−2.1	−3.7
Cdca2	−2.6	−2.9	Tuba3b	−2.3	−2.3
Cdca3	−2.5	−4.1	Upp1	−2.4	−2.3
Cdca5	−2.9	−3.2	Wars	−2.9	−2.7
Cdkn3	−2.2	−2.5	Zbtb32	−5.3	−8.1
Cenpi	−2.1	−2.8	Actn1	2.2	2.1
Cenpn	−2.7	−3.2	AI467606	2.2	2.7
Cep55	−2.2	−3.8	Alox5ap	2.1	2.6
Chaf1a	−2.3	−3.4	Anxa3	2.2	3.9
Chaf1b	−2.0	−2.7	Apoe	3.1	4.0
Chchd6	−2.1	−2.7	Apol7c	4.8	4.4
Clspn	−2.1	−4.1	Arhgef18	2.1	2.9
Cox6a2	−3.1	−10.6	Arsj	2.9	4.7
Cxcl10	−6.6	−5.9	Atg16l2	2.0	2.5
Dlgap5	−2.0	−2.7	Bcl11b	2.1	2.2
E2f1	−2.1	−2.9	Ccl9	2.2	3.2
Esco2	−2.0	−3.9	Cd27	2.1	2.1
Espl1	−2.2	−2.2	Cd68	2.3	2.3
Fancd2	−2.5	−3.1	Cd8b1	2.0	2.5
Fanci	−2.3	−2.4	Clec4d	2.6	2.5
Fcgr4	−4.2	−2.8	Clec4n	2.3	3.0
Fdps	−2.1	−2.8	Crhbp	4.1	5.0
Ffar2	−16.3	−13.5	Crxos1	2.0	2.5
Fgl2	−4.9	−4.5	Cxcl4	2.5	3.4
Galk1	−2.0	−2.8	Egr2	3.1	2.1
Gbp1	−2.0	−2.0	Egr3	3.1	2.7
Gbp2	−7.6	−4.9	Emb	2.1	2.1
Gbp3	−3.6	−2.4	Emr1	3.5	2.6
Gbp6	−3.8	−3.0	Ephx1	2.2	4.5
Gins1	−2.7	−4.2	Etsrp71	2.8	3.8
Gmnn	−2.0	−2.1	Faim3	2.9	3.4
Gmppb	−2.6	−2.5	Fcer2a	2.0	2.6
Gng12	−3.1	−3.4	Flrt3	2.9	3.8
Gpr109a	−2.3	−2.1	Gad1	2.0	3.1
Grhpr	−2.7	−2.2	Gli3	2.2	2.7
Hist1h2ag	−2.3	−2.7	Gpnmb	3.0	4.4
Hist1h3c	−2.4	−2.2	H2-M2	4.0	3.3
Hist2h2ab	−2.5	−2.7	Icam2	2.0	2.6
Hnrpab	−2.1	−2.6	Il11ra1	2.1	2.6
Hyou1	−2.0	−2.4	Il7r	2.2	2.5
Ifi47	−4.5	−3.4	Irx5	2.4	3.2
Ifng	−11.1	−7.3	Kcnrg	2.5	2.4
Iigp2	−3.1	−2.5	Kctd11	2.0	2.0
Il12rb1	−2.5	−2.4	Klrd1	2.6	3.9
Incenp	−2.2	−2.7	Kpnb3	3.3	3.2
Indo	−2.6	−2.3	Lgals3	2.1	4.2
Ipo5	−2.0	−2.9	Lpl	2.9	4.3
Irg1	−5.8	−5.6	Ltf	3.3	6.6
Irgb10	−6.7	−6.7	Ly116	2.3	3.4
Isg20	−3.7	−3.0	Lyz	4.2	5.0
Jun	−3.7	−3.2	Lyz2	7.3	6.7
Kif11	−2.5	−3.7	Lyzs	3.8	4.9
Kif15	−2.6	−2.9	Mafg	2.2	2.3
Kif22	−2.1	−2.8	Mdga2	2.7	2.3
Kif4	−2.7	−3.2	Mmp9	2.1	2.7
Kntc1	−2.1	−3.4	Msmb	2.4	2.0
Lgals9	−2.2	−2.3	Nagk	2.2	3.2
Lig1	−2.4	−3.0	Ngp	3.1	2.8
Ly6a	−2.4	−2.2	Nrp1	2.1	2.2
Mad2l2	−2.4	−2.1	Pcdhga2	2.2	2.6
Mcm10	−2.2	−5.2	Pdcd4	2.0	2.7
Mcm2	−2.2	−2.4	Pira3	2.2	2.7
Mcm7	−2.1	−3.1	Prl4a1	2.3	2.3
Mid1ip1	−2.5	−2.9	Punc	2.4	2.7
Mlkl	−3.3	−4.4	Rab5b	2.3	2.7
Mrps28	−2.2	−2.2	Rasl2-9	2.3	2.0
Mybl2	−2.7	−2.8	Rgl2	2.1	2.8
Ncapd2	−2.2	−2.6	Rgs10	2.4	2.8
Ncaph	−2.2	−4.5	Rnf122	2.1	3.0
Ndc80	−2.3	−2.0	Rnu6	2.3	2.6
Ndufb9	−2.1	−2.1	S100a8	3.4	4.0
Nmral1	−3.9	−3.6	S100a9	2.9	4.7
Noc4l	−2.4	−2.4	Sesn1	2.1	3.2
Nudt1	−2.2	−2.1	Sgk1	2.1	2.8
Nusap1	−2.2	−2.8	Siat7c	2.6	3.4
Oasl1	−7.7	−3.8	Sirpa	2.2	3.7
Oosp1	−2.0	−3.2	Slc11a1	3.1	2.5
Paics	−2.0	−2.3	Slc40a1	2.7	3.4
Pdss1	−2.1	−3.5	Smpdl3a	2.0	3.4
Pgk1	−2.1	−3.6	Snn	2.0	2.2
Phf11	−6.9	−3.4	Sspn	2.2	4.0
Phf19	−2.6	−2.6	Tax1bp3	2.1	2.3
Pkm2	−2.0	−2.5	Tmem71	2.1	2.0
Plk1	−2.2	−4.3	Tmie	2.4	2.8
Pole	−2.1	−3.0	Trat1	2.2	2.9
Prc1	−2.0	−3.6	Trp53inp1	2.0	2.0
Psmb9	−3.8	−2.3	Vmn2r42	3.1	2.8
Rrm1	−2.6	−3.4	Wdr9	2.0	2.3
Rrm2	−2.4	−3.2	Wnt10a	3.8	2.1