Activation of AMP-Activated Protein Kinase and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells
(a) Chemical structure of CB-PIC. Molecular weight = 582. (b) SW620, HC116, and HT29 cells were treated with various concentrations of CB-PIC (0, 25, 50, or 100 g/mL) for 4 and 6 hr. Cell viability was analyzed by MTT assay. (c) Cells were exposed to normoxia or hypoxia for 6 hours with CB-PIC (0, 25 or 50 g/mL). Data are presented as means SD. compared with control and compared with hypoxia control.