Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity
Identification of acylcarnitines as serum biomarkers of WZ protective effect on APAP-induced hepatic toxicity through metabolomic analysis. (a) Scores scatter plot of a PCA model on the serum metabolome of control (*), WZ-treated (▲), WZ/APAP-treated (•), and APAP-treated (◆) mice. (b) Loadings scatter plot from the PCA analysis of serum from control, WZ-treated, WZ/APAP-treated, and APAP-treated mice. Data points representing palmitoylcarnitine (P1), oleoylcarnitine (P2), myristoylcarnitine (P3), and palmitoleoylcarnitine (P4) were labeled in the plot.