Research Article

Comparison between Chinese Herbal Medicines and Conventional Therapy in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

Table 1

Characteristics of participants with severe HFMD.

Characteristic Conventional therapy group ( )Reduning injection combination therapy group ( )TCM formulas combination therapy group ( )

Male, (%)73 (64.6)83 (68.0)79 (65.8)
Mean age ± SD, y
Temperature, (%)
 37.5–38.0°C38 (33.6)42 (34.4)41 (34.2)
 38.1–39.0°C60 (53.1)58 (47.5)62 (51.7)
 >39.0°C15 (13.3)22 (18.0)17 (14.2)
Symptom, (%)
 Cough9 (8.0)9 (7.4)13 (10.9)
 Sleepiness29 (26.1)25 (20.8)27 (22.7)
 Headache3 (2.7)6 (5.0)4 (3.4)
 Irritability11 (9.8)12 (10.0)10 (8.5)
 Fatigue66 (58.9)69 (58.0)73 (60.8)
 Skin or oral mucosal lesions76 (67.2)70 (57.4)79 (65.8)
Height (SD), cm87.43 (13.48)88.53 (14.34)87.14 (11.47)
Body weight (SD), kg12.68 (2.94)12.93 (3.75)12.61 (3.07)