Ameliorative Effect of Hexane Extract of Phalaris canariensis on High Fat Diet-Induced Obese and Streptozotocin-Induced Diabetic Mice

Table 13

Effect of hexane extract of P. canariensis on serum and pancreatic insulin concentration of normal and diabetic mice.

Groups	Before administration; (0 h)	Plasma insulin; (𝜇IU/mL)	Pancreatic insulin; (𝜇IU/mL)
Normal control	3.59±0.52	3.60±0.15	25.80±3.76
SD control	0.77±0.084	1.50±0.29^a	15.21±5.43^a
MD control	0.76±0.032	^d1.61±0.36^b	15.02±5.13^bc
SD + AL	0.74±0.019	^d3.17±0.51^b	21.24±6.38^bc
MD + AL	0.77±0.037	^d3.27±0.54^b	21.68±6.18^bc
SD + glibenclamide 4 mg/kg	0.75±0.070	3.49±0.34^b	19.35±3.23^bc

All values are expressed as mean ± SD, 𝑛=6 values. Plasma insulin values at 0 h before drug administration are significantly different compared to respective 30 days after drug treatment. Significant difference of diabetic control from normal control ^a𝑃<0.001. Significant difference of treated groups from diabetic control ^b𝑃<0.01, ^c𝑃<0.05. ^d𝑃<0.01 when compared with glibenclamide 4 mg/kg treated group.