Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 1

Review Article

Chinese Herbal Medicine on Dyslipidemia: Progress and Perspective

Table 1

The most frequently used single Chinese herbs for dyslipidemia.

NumberHerbsDosage/administration/timeEffectsComponentsReferences

1Radix et. Rhizoma Rhei (Dahuang)Human: powder, 5 g/day, Po, 24 weeks; Db/db mice: rhein, 150 m/kg/day, Po, 12 weeksTG TC LDL-CAnthraquinones[7, 8]
2Rhizoma ploygoni cuspidate 
(Hu Zhang)
Rabbits: polydatin, 25 mg, 50 mg, 100 mg/kg/day Po, 3 weeks; SD rats: resveratrol 30, 70 mg/kg Po, 4 weeksTG TC LDL-CPolydatin, resveratrol, and emodin[12, 13, 15]
3Semen Cassia 
(Jumingzi)
SD rats: extracts, 8, 15, 25 mg/kg Po, 35 days; SD rats: anthraquinones, 0.1, 0.2, 0.4 g/kg Po, 2 monthsTG TC LDL-CAnthraquinones, protein[18, 20]
4Coptis chinensis
(Huanglian)
Human: berberine, 500 mg tid Po, 12 weeks; SD rats: berberine, 200 mg/kg/day ip, 16 weeks; SD rats: berberine 75 mg, 150 mg, 300 mg/kg/day po 16 weeksTC LDL-C TG HDL-c↑ Alkaloid berberine[2224]
5Scutellaria baicalensis
(Huangqin)
SD rats: SSTF, 75 mg, 150 mg/kg Po, 25 days;TC LDL-C TG HDL-c↑ Flavonoid[25]
6Gynostemma pentaphylla
(Jiaogulan)
Mice: powder, 250 mg/kg, Po, 4-day; SD rats: extract, 50 mg, 200 mg/kg/day, Po, 4 weeksTG TC LDL-CGypenoside[26, 27]
7Radix Puerariae 
(Gegen)
Wistar rats: puerarin, 50 mg/kg/day ip, 30 days; ovariectomized rats: flavones, 100 mg/kg/day, po, 5 weeksTC LDL-C TG HDL-c↑ Puerarin[28, 29]
8Fructus crataegi 
(Shan zha)
Human: aqueous extracts, 3.6 g/kg, Po, 3 months; rats: ethanol extracts, 30 mg, 100 mg/kg/day. Po., 4 weeksTG TC LDL-CFlavonoids, triterpenic acids[30, 31]
9Red yeast rice 
(Hongqu)
Human: rice, 600 mg/day, Po, 8 weeks; human: rice, 1.2 mg, po, 6 months–1 yearTC LDL-C TGLovastatin, sterols, Isoflavones and isoflavone glycosides, and MUFA[32, 33]
10Rhizoma chuanxiongRats: ligustrazine, 20 mg, 80 mg/kg, Po, 6 weeks; rabbits: ligustrazine, 75 mg, 150 mg/kg/day, Po, 12 weeksTG TC LDL-CLactones, total alkaloids[34, 35]
11Radix salvia miltiorrhizae 
(Danshen)
Rats: extracts, 50, 100, 150 mg/kg/day, Po, 4 weeks; human: tanshinone IIA, 80 mg/day, ivgtt. 14 daysTC LDL-C TG HDL-c↑ Tanshinone IIA[36, 37]
12Turmerone 
(Jianghuang)
Hamsters: curcumin, 0.05 g/100 g, Po, 10 weeks; SD rats: curcumin, 40, 80, 160 mg/kg, Po, 4 weeks.TC LDL-C TG FFA HDL-c↑ Curcumin[38, 39]
13Rhizoma alismatis 
(Zexie)
Human: powders, 10 g/day, Po, 2 weeks; SD rats: extracts, 0.3 mL/day, Po, 21 days.TC LDL-C TGTriterpenes[40, 41]
14Plantain seed 
(Cheqianzi)
Human: polysaccharides, 14 g/day, Po, 8 weeks; rats: powder, 15 g/kg, Po, 12 weeks; pig: plantain seed, 7.5, 10 g/100 mg, po, 4 weeks.TC LDL-C TGPolysaccharides[4244]
15Folium nelumbinis 
(Heye)
SD rats: aqueous extracts, 400 mg/kg/day, Po, 6 weeks; mice: flavonoids, 50, 200 mg/kg/day, Po, 28 days.TC LDL-C TGTotal flavonoids, 
alkaloid
[45, 46]
16Radix Astragali 
(Huangqi)
Rat: extracts, 0.4%, 0.8%, Po, 5 weeks; rat: polysaccharides, 40, 100 mg/kg/day, Po, 40 days.TC LDL-C TG HDL-c↑ Polysaccharides, 
flavonoid, and 
saponin
[47, 48]
17Radix Ginseng  (Renshen)Mice: ginsenoside, 2 mg/kg/days, Po, 90 days; rats: ginsenoside Rb, 50 mg, 100 mg, 200 mg/kg/day, Po, 12 daysTC LDL-C TG HDL-c↑ Ginsenoside, 
ginseng, and polysaccharides
[49, 50]
18Radix Polygoni Multiflori 
(Heshouwu)
Rats: extracts, 12, 24 mg/kg/day, Po, 4 weeks; rats: EAEF, 30, 60 mg/kg/day, Po, 28 days.TC LDL-C TG HDL-c↑ Anthraquinones, 
polysaccharides 
[51, 52]