Pharmacokinetic Comparative Study of Gastrodin and Rhynchophylline after Oral Administration of Different Prescriptions of Yizhi Tablets in Rats by an HPLC-ESI/MS Method

Table 6

Pharmacokinetic parameters for metabolites in rat plasma after oral administration of Yizhi tablets, EPT, or EPG ().

Parameters	Unit	Yizhi tablet group			EPT group			EPG group
		GAS	HBA	RIN	GAS	HBA	RIN	GAS	HBA	RIN
	min	45 ± 0.0	55 ± 12.25	240 ± 0.0	21.67 ± 4.08	60 ± 0.0				220 ± 48.99
	μg mL^−1	140.72 ± 19.05	10.45 ± 3.02	6.50 ± 1.44	188.45 ± 19.33	9.12 ± 0.61				6.17 ± 0.38
	μg min mL^−1	13816.35 ± 445.39	2267.27 ± 158.92	1783.54 ± 411.33	21549.67 ± 2302.7	1656.31 ± 77.34				2414.50 ± 157.78
	μg min mL^−1	14910.3 ± 509.41	3129.68 ± 138.9	1918.26 ± 540.62	22048.87 ± 2408.02	2080.71 ± 214.3				2604.81 ± 266.89
	min	161.69 ± 4.69	266.67 ± 14.7	223.06 ± 17.10	121.74 ± 2.03	154.12 ± 4.6				286.94 ± 16.02
	min	197.31 ± 5.44	553.26 ± 71.54	275.13 ± 68.43	132.43 ± 3.73	238.75 ± 39.79				335.55 ± 44.75
CL/F	mL min^−1 kg^−1	3.50 ± 0.10	—	2.18 ± 0.46	2.32 ± 0.25	—				1.55 ± 0.13