Review Article

Chinese Patent Medicine Tongxinluo Capsule for Hypertension: A Systematic Review of Randomised Controlled Trials

Table 1

Characteristics and methodological quality of included studies.

Study IDSampleAge Diagnosis standard Intervention ControlCourseOutcome measure
(M/F)(yrs)(week)

F.M. Liu and C. F. Liu, 2009 [41]60
T: 21/10; 
C: 20/9
41 to 76 (T/C not reported)1999 WHO-ISH GMHTXL + CAmlodipine (5 mg qd)8
(3 pills/time, tid)
BP;
Adverse event
Li et al.
2003 [42]
86
T: 44; C: 42  
 M/F: 54/32
60 to 75 (T/C not reported)1999 WHO-ISH GMH TXL + CNifedipine controlled released tablets (30 mg qd)12
(3 pills /time, tid)
BP;
Adverse event
Lu et al.
2012 [43]
94
T: 48; C: 46 
M/F: 59/35
. (T/C not reported)1999 WHO-ISH GMHTXL + CNifedipine controlled released tablets (30 mg qd)24 (0.38 g/pill, 4 pills/time, tid)BP
Xie, 2006 [44]60
T: 18/12  
C: 20/10
T:   
C:
Hypertension diagnostic criteria (unclear)TXL + CBenazepril Hydrochloride tablets (10 mg qd)24
(0.38 g/pill, 4 pills/time, tid)
BP
Wei and Chen,
2009 [45]
93
T: 18/25 
C: 21/29
T:   
C:
Chinese Guidelines for the Management of Hypertension-2004 (CGMH-2004)TXL + CWestern medicine24
(4 pills/time, tid)
BP
Xu et al.
2009 [46]
100
T: 36/14  
C: 38/12
40–79
(T/C not reported)
Chinese Guidelines for the Management of Hypertension-2004 (CGMH-2004)TXL + CWestern medicine24 (3 pills/time, bid)BP
Zhao and Cheng, 2010 [47]90
T: 26/19  
C: 33/12
T:
C:
1999 WHO-ISH GMHTXL + CIrbesartan tablets (150 mg qd)24 (3 pills/time, tid)BP;
Adverse event
Xu et al.
2007 [48]
72
T: 36; C: 36  
M/F: 59/35
(T/C not reported)1999 WHO-ISH GMHTXL + CWestern medicine8 (3 pills/time, tid)BP
Zhu, 2011 [49]61
T: 30; C: 31  
(M/F not reported)
45–70
(T/C not reported)
Chinese Guidelines for the Management of Hypertension-2005 (CGMH-2005)TXL + CFelodipine sustained release tablets (2.5–5.0 mg)6 (3 pills/time, tid)BP
Rao, 2009 [50]147
T: 41/33  
C: 39/34
T:   
C:
Chinese Guidelines for the Management of Hypertension-2000 (CGMH-2000)TXL + CNifedipine controlled release tablets (10 mg bid); Captopril (25 mg tid)12 (0.26 g/pill, 4 pills/time, tid)BP;
Adverse event
Mo et al. 2009 [51]240
T: 79/41  
C: 76/44
T:   
C:
Chinese Guidelines for the Management of Hypertension-2005 (CGMH-2005)TXL + CFosinopril sodium tablets (10 mg qd)12 (0.26 g/pill, 3 pills/time, tid)BP;
Adverse event
Xu,
2005 [52]
52
T: 19/8  
C: 18/7
T: 40–76  
C: 41–76
1999 WHO-ISH GMHTXL + CAmlodipine (5 mg qd)8 (3 pills/time, tid)BP;
Adverse event
Li et al.
2012 [53]
81
T: 40  
C: 41  
M: 81
65 to 80 (T/C not reported)The management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) 2007TXL + CCandesartan (8 mg qd)12 (3 pills/time, tid)BP
Cheng et al.
2011 [54]
108
T: 39/29  
C: 23/17
T:   
C:
Chinese Guidelines for the Management of Hypertension-2005 (CGMH-2005)TXL + C Losartan (50–100 mg qd)4 (3 pills/time, tid)BP
Wang, 2011 [55]194
T: 57/40  
C: 58/39
T: 42–74  
C: 41–73
1999 WHO-ISH GMHTXL + CNifedipine sustained release tablets (10 mg bid)4 (3 pills/time, bid)BP;
Adverse event
Chen et al.
2011 [56]
178
T: 49/40  
C: 47/42
T:   
C:
Chinese Guidelines for the Management of Hypertension-2005 (CGMH-2005)TXL + CValsartan capsules (80–160 mg qd)24 (4 pills/time, tid)BP;
Adverse event
Liao,
2006 [57]
80
T: 22/18  
C: 24/16
T:   
C:
1999 WHO-ISH GMHTXL + CWestern medicine16 (3 pills/time, tid)BP
Zhang,
2011 [58]
60
T: 30  
C: 30  
(M/F not reported)
(T/C not reported)Chinese Guidelines for the Management of Hypertension-2005 (CGMH-2005)TXL + CValsartan (160 mg qd)8 (3 pills/time, tid)BP
Yan and He, 2007 [59]102  
T: 32/20  
C: 29/21
T: 40–74  
C: 41–75
1999 WHO-ISH GMHTXL + CAmlodipine Benzenesulfonate tablets (5 mg qd)
4 (0.38 g/pill, 3 pills/time, bid)BP;
Adverse event
Jiang, 2011 [60]76  
T: 26/12  
C: 24/14
T:   
C:
1999 WHO-ISH GMHTXL + CBenazepril (10 mg qd)
24 (3 pills/time, tid)BP
Wang et al.
2004 [61]
193  
T: 58/39  
C: 57/39
T: 41–73  
C: 40–73
1999 WHO-ISH GMHTXL + CNifedipine sustained release tablets (10 mg bid)4 (0.38 g/pill, 3 pills/time, bid)BP;
Adverse event
Lu and Zha,
2005 [62]
77  
M/F: 37/40  
(T/C not reported)
1999 WHO-ISH GMHTXL + CWestern medicine8 (4 pills/time, tid)BP
Hu, 2013 [63]76  
T: 28/15  
C: 19/14
T: 39–73  
C: 34–65
Hypertension diagnostic criteria (unclear)TXL + CEnalapril (2.5 mg bid)52 (2–4 pills/time, tid)BP;
Adverse event
Lu and Zhou, 2007 [64]45  
T: 23  
C: 22  
M/F: 25/20  
(T/C not reported)
  
(T/C not reported)
Chinese Guidelines for the Management of Hypertension-2005 (CGMH-2005)TXLPlacebo 6 (3 pills/time, tid)BP;
Adverse event
Zhao et al.
2007 [65]
60  
T: 30  
C: 30  
M/F: 34/26  
(T/C not reported)
55–75  
(T/C not reported)
Hypertension diagnostic criteria (unclear)TXLCaptopril (50 mg bid)4 (0.38 g/pill, 4 pills/time, bid)BP