Thirteen-Week Study of PM014 Subchronic Oral Toxicity in Rats

Table 3

Biochemical parameters of rats treated orally with PM014 for 13 weeks.

Biochemical parameters	PM014 (mg/kg/day)
	0	750	1500	3000
Males
AST (U/L)	86.3±7.7	85.9±12.3	85.5±6.8	87.5±12.8
ALT (U/L)	40.5±4.3	40.1±4.5	39.8±4.9	42.3±9.0
ALP (U/L)	74.4±18.4	78.7±10.3	78.9±15.5	81.4±12.2
CPK (U/L)	130.5±62.4	118.1±69.7	120.6±65.1	109.9±62.0
TBIL (mg/dL)	0.17±0.02	0.19±0.03	0.20±0.02	0.19±0.01
GLU (mg/dL)	156.1±17.0	145.3±13.7	151.4±24.9	145.2±18.7
TCHO (mg/dL)	112.2±17.5	113.0±25.3	106.2±12.3	111.0±23.4
TG (mg/dL)	40.7±11.3	41.3±9.2	43.3±11.8	46.6±12.0
TP (g/dL)	6.48±0.36	6.51±0.33	6.44±0.11	6.32±0.18
ALB (g/dL)	3.11±0.17	3.10±0.08	3.08±0.06	3.02±0.11
A/G (ratio)	0.92±0.03	0.91±0.07	0.92±0.03	0.91±0.03
BUN (mg/dL)	18.6±2.5	17.5±2.3	18.6±2.2	18.6±3.1
CRE (mg/dL)	0.50±0.04	0.49±0.04	0.50±0.04	0.47±0.02
IP (mg/dL)	6.66±0.54	6.71±0.43	6.80±0.62	6.79±0.42
Ca^2+ (mg/dL)	10.55±0.38	10.79±0.37	10.61±0.26	10.54±0.18
Na^+ (mmol/L)	139.71±1.54	139.74±1.14	139.94±0.98	139.69±1.00
K^+ (mmol/L)	4.90±0.60	4.72±0.31	4.85±0.51	4.74±0.27
Cl^− (mmol/L)	101.88±1.51	101.18±1.20	101.88±0.98	102.32±1.19
Females
AST (U/L)	89.5±10.9	86.1±9.8	91.0±23.2	88.7±10.3
ALT (U/L)	36.4±5.2	34.9±5.0	40.1±10.5	36.6±5.2
ALP (U/L)	55.0±14.3	63.8±11.8	61.1±8.5	70.9±10.6^∗∗
CPK (U/L)	126.8±47.3	123.7±71.7	104.0±33.2	122.5±58.0
TBIL (mg/dL)	0.20±0.02	0.21±0.03	0.21±0.02	0.23±0.03^∗
GLU (mg/dL)	123.1±13.0	125.1±13.9	120.4±11.2	115.5±5.5
TCHO (mg/dL)	114.6±24.8	108.1±18.2	98.2±9.2	96.6±15.3
TG (mg/dL)	41.7±11.0	33.7±4.6	35.5±7.8	33.5±6.2
TP (g/dL)	6.37±0.35	6.31±0.31	6.27±0.17	6.24±0.29
ALB (g/dL)	3.30±0.21	3.27±0.22	3.29±0.11	3.26±0.15
A/G (ratio)	1.08±0.04	1.08±0.07	1.10±0.06	1.10±0.05
BUN (mg/dL)	21.1±3.4	19.2±1.8	20.1±2.5	20.2±3.1
CRE (mg/dL)	0.60±0.06	0.62±0.05	0.60±0.06	0.59±0.06
IP (mg/dL)	5.50±0.66	5.68±0.72	6.24±1.16	6.19±0.49
Ca^2+ (mg/dL)	10.10±0.28	10.09±0.23	10.21±0.20	10.05±0.24
Na^+ (mmol/L)	139.53±1.43	139.17±0.94	139.81±1.51	139.43±1.09
K^+ (mmol/L)	4.15±0.19	4.18±0.37	4.38±0.51	4.40±0.34
Cl^− (mmol/L)	103.89±1.47	103.94±1.34	104.60±1.06	104.79±1.38

AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase; CPK: creatine phosphokinase; TBIL: total bilirubin; GLU: glucose; TCHO: total cholesterol; TG: triglyceride; TP: total protein; ALB: albumin; A/G: albumin/globulin ratio; BUN: blood urea nitrogen; CRE: creatinine; IP: inorganic phosphorus. The data shown are the means ± SD (𝑛=10/group).
^∗𝑃<0.05, ^∗∗𝑃<0.01 compared with the control group.